Pulmonary toxicity of well-dispersed titanium dioxide nanoparticles following intratracheal instillation

In order to investigate the pulmonary toxicity of titanium dioxide (TiO 2 ) nanoparticles, we performed an intratracheal instillation study with rats of well-dispersed TiO 2 nanoparticles and examined the pulmonary inflammation and histopathological changes in the lung. Wistar Hannover rats were int...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2015-06, Vol.17 (6), p.241-11, Article 241
Main Authors: Yoshiura, Yukiko, Izumi, Hiroto, Oyabu, Takako, Hashiba, Masayoshi, Kambara, Tatsunori, Mizuguchi, Yohei, Lee, Byeong Woo, Okada, Takami, Tomonaga, Taisuke, Myojo, Toshihiko, Yamamoto, Kazuhiro, Kitajima, Shinichi, Horie, Masanori, Kuroda, Etsushi, Morimoto, Yasuo
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry and Materials Science
Disorders
Fibrosis
Fluid dynamics
Inorganic Chemistry
Lasers
Lungs
Materials Science
Nanoparticles
Nanotechnology
Optical Devices
Optics
Photonics
Physical Chemistry
Rats
Research Paper
Titanium dioxide
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In order to investigate the pulmonary toxicity of titanium dioxide (TiO 2 ) nanoparticles, we performed an intratracheal instillation study with rats of well-dispersed TiO 2 nanoparticles and examined the pulmonary inflammation and histopathological changes in the lung. Wistar Hannover rats were intratracheally administered 0.2 mg (0.66 mg/kg) and 1.0 mg (3.3 mg/kg) of well-dispersed TiO 2 nanoparticles (P90; diameter of agglomerates: 25 nm), then the pulmonary inflammation responses were examined from 3 days to 6 months after the instillation, and the pathological features were examined up to 24 months. Transient inflammation and the upregulation of chemokines in the broncho-alveolar lavage fluid were observed for 1 month. No respiratory tumors or severe fibrosis were observed during the recovery time. These data suggest that transient inflammation induced by TiO 2 may not lead to chronic, irreversible legions in the lung, and that TiO 2 nanoparticles may not have a high potential for lung disorder.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-015-3054-x