Structural‐equation‐modelling of the tropism impact on achieving viral suppression within six months in naïve HIV patients

• Published in: Journal of the International AIDS Society 2014-11, Vol.17 (4 Suppl 3), p.19679-n/a
• Main Authors: Mengoli, Carlo, Andreis, Samantha, Scaggiante, Renzo, Cruciani, Mario, Bosco, Oliviero, Ferretto, Roberto, Leone, D., Maffongelli, Gaetano, Basso, Monica, Sarmati, Loredana, Andreoni, Massimo, Palù, Giorgio, Giuseppe Parisi, Saverio
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; AIDS; Antiviral agents; Development and progression; Dosage and administration; Drug therapy; Drug therapy, Combination; HIV; HIV infection; Human immunodeficiency virus; Patient outcomes; Plasma; Structural equation modeling; Tropisms; Virus research
• ISSN: 1758-2652; 1758-2652
• DOI: 10.7448/IAS.17.4.19679

Introduction Aim of the study was to evaluate the relevance of baseline (BL) plasma tropism of HIV on the achievement of a viral suppression within six months of antiviral therapy (ARV) in naïve patients by a structural‐equation‐modelling. Materials and Methods Two‐hundred and twenty‐seven patients were enrolled; viral tropism on plasma was determined at baseline (BL) by sequencing and interpretation by genotopheno algorithm. Booster atazanavir or lopinavir, or efavirenz or nevirapine were used, in combination with either abacavir/lamivudine or tenofovir‐emtricitabine. Results X4‐tropism correlate negatively with CD4 cell count at BL and follow‐up (FU), and CD4 correlate negatively with BL‐plasma viremia (PLV). BL‐PLV correlate positively with FU‐PLV. We have developed the hypothesis that the variables BL‐CD4 and BL‐PLV represent a mediators chain among X4‐tropism and outcome of plasma viraemia at six months. This model, after structural‐equation‐modelling (SEM, Stata13), is shown in Figure 1. The indirect effect of X4‐tropism on Fup‐PLV is significant (p