Effect of naturally occurring ozone air pollution episodes on pulmonary oxidative stress and inflammation

This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chro...

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Bibliographic Details
Published in:International journal of environmental research and public health 2015-05, Vol.12 (5), p.5061-5075
Main Authors: Pirozzi, Cheryl, Sturrock, Anne, Weng, Hsin-Yi, Greene, Tom, Scholand, Mary Beth, Kanner, Richard, Paine, 3rd, Robert
Format: Article
Language:English
Subjects:
Air Pollution
Biomarkers - metabolism
Breath Tests
Environmental Monitoring
Female
Humans
Inflammation
Lung - drug effects
Male
Middle Aged
Oxidative Stress - drug effects
Ozone
Ozone - toxicity
Pneumonia - chemically induced
Public health
Pulmonary Disease, Chronic Obstructive - pathology
Respiratory diseases
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Summary:This study aimed to determine if naturally occurring episodes of ozone air pollution in the Salt Lake Valley in Utah, USA, during the summer are associated with increased pulmonary inflammation and oxidative stress, increased respiratory symptoms, and decreased lung function in individuals with chronic obstructive pulmonary disease (COPD) compared to controls. We measured biomarkers (nitrite/nitrate (NOx), 8-isoprostane) in exhaled breath condensate (EBC), spirometry, and respiratory symptoms in 11 former smokers with moderate-to-severe COPD and nine former smokers without airflow obstruction during periods of low and high ozone air pollution. High ozone levels were associated with increased NOx in EBC in both COPD (8.7 (±8.5) vs. 28.6 (±17.6) μmol/L on clean air vs. pollution days, respectively, p < 0.01) and control participants (7.6 (±16.5) vs. 28.5 (±15.6) μmol/L on clean air vs. pollution days, respectively, p = 0.02). There was no difference in pollution effect between COPD and control groups, and no difference in EBC 8-isoprostane, pulmonary function, or respiratory symptoms between clean air and pollution days in either group. Former smokers both with and without airflow obstruction developed airway oxidative stress and inflammation in association with ozone air pollution episodes.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph120505061