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In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: the CHAMACOS study

Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. In this study, we examined whether pre- and postna...

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Published in:Environmental health perspectives 2015-06, Vol.123 (6), p.636-636
Main Authors: Erkin-Cakmak, Ayca, Harley, Kim G, Chevrier, Jonathan, Bradman, Asa, Kogut, Katherine, Huen, Karen, Eskenazi, Brenda
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cited_by cdi_FETCH-LOGICAL-c679t-4cf977d3b882261cda359710f9d4dfe3149af66b79e5ccbaa71878c8f95105873
cites cdi_FETCH-LOGICAL-c679t-4cf977d3b882261cda359710f9d4dfe3149af66b79e5ccbaa71878c8f95105873
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container_title Environmental health perspectives
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creator Erkin-Cakmak, Ayca
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Huen, Karen
Eskenazi, Brenda
description Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. In this study, we examined whether pre- and postnatal exposure to the components of pentaBDE mixture was associated with childhood obesity in a population of Latino children participating in a longitudinal birth cohort study in the Salinas Valley, California. We measured PBDEs in serum collected from 224 mothers during pregnancy and their children at 7 years of age, and examined associations with body mass index (BMI) at age 7 years. Maternal PBDE serum levels during pregnancy were associated with higher BMI z-scores in boys (BMI z-score βadjusted = 0.26; 95% CI: -0.19, 0.72) but lower scores in girls (BMI z-score βadjusted = -0.41; 95% CI: -0.87, -0.05) at 7 years of age (pinteraction = 0.04). In addition, child's serum BDE-153 concentration (log10), but not other pentaBDE congeners, demonstrated inverse associations with BMI at age 7 years (BMI z-score βadjusted = -1.15; 95% CI: -1.53, -0.77), but there was no interaction by sex. We estimated sex-specific associations with maternal PBDE levels during pregnancy and BMI at 7 years of age, finding positive associations in boys and negative associations in girls. Children's serum BDE-153 concentrations were inversely associated with BMI at 7 years with no difference by sex. Future studies should examine the longitudinal trends in obesity with PBDE exposure and changes in hormonal environment as children transition through puberty, as well as evaluate the potential for reverse causality.
doi_str_mv 10.1289/ehp.1408417
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Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. In this study, we examined whether pre- and postnatal exposure to the components of pentaBDE mixture was associated with childhood obesity in a population of Latino children participating in a longitudinal birth cohort study in the Salinas Valley, California. We measured PBDEs in serum collected from 224 mothers during pregnancy and their children at 7 years of age, and examined associations with body mass index (BMI) at age 7 years. Maternal PBDE serum levels during pregnancy were associated with higher BMI z-scores in boys (BMI z-score βadjusted = 0.26; 95% CI: -0.19, 0.72) but lower scores in girls (BMI z-score βadjusted = -0.41; 95% CI: -0.87, -0.05) at 7 years of age (pinteraction = 0.04). 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Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. In this study, we examined whether pre- and postnatal exposure to the components of pentaBDE mixture was associated with childhood obesity in a population of Latino children participating in a longitudinal birth cohort study in the Salinas Valley, California. We measured PBDEs in serum collected from 224 mothers during pregnancy and their children at 7 years of age, and examined associations with body mass index (BMI) at age 7 years. Maternal PBDE serum levels during pregnancy were associated with higher BMI z-scores in boys (BMI z-score βadjusted = 0.26; 95% CI: -0.19, 0.72) but lower scores in girls (BMI z-score βadjusted = -0.41; 95% CI: -0.87, -0.05) at 7 years of age (pinteraction = 0.04). 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Future studies should examine the longitudinal trends in obesity with PBDE exposure and changes in hormonal environment as children transition through puberty, as well as evaluate the potential for reverse causality.</description><subject>Adipocytes</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Androgens</subject><subject>Body Mass Index</subject><subject>Body size (biology)</subject><subject>California - epidemiology</subject><subject>Child</subject><subject>Children</subject><subject>Children &amp; youth</subject><subject>Children's Health</subject><subject>Chromatography</subject><subject>Disease control</subject><subject>Endocrine system</subject><subject>Environmental aspects</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - blood</subject><subject>Estrogens</subject><subject>Ethers</subject><subject>Exposure</subject><subject>Female</subject><subject>Fire resistant materials</subject><subject>Flame retardants</subject><subject>Flame Retardants - 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Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. In this study, we examined whether pre- and postnatal exposure to the components of pentaBDE mixture was associated with childhood obesity in a population of Latino children participating in a longitudinal birth cohort study in the Salinas Valley, California. We measured PBDEs in serum collected from 224 mothers during pregnancy and their children at 7 years of age, and examined associations with body mass index (BMI) at age 7 years. Maternal PBDE serum levels during pregnancy were associated with higher BMI z-scores in boys (BMI z-score βadjusted = 0.26; 95% CI: -0.19, 0.72) but lower scores in girls (BMI z-score βadjusted = -0.41; 95% CI: -0.87, -0.05) at 7 years of age (pinteraction = 0.04). In addition, child's serum BDE-153 concentration (log10), but not other pentaBDE congeners, demonstrated inverse associations with BMI at age 7 years (BMI z-score βadjusted = -1.15; 95% CI: -1.53, -0.77), but there was no interaction by sex. We estimated sex-specific associations with maternal PBDE levels during pregnancy and BMI at 7 years of age, finding positive associations in boys and negative associations in girls. Children's serum BDE-153 concentrations were inversely associated with BMI at 7 years with no difference by sex. Future studies should examine the longitudinal trends in obesity with PBDE exposure and changes in hormonal environment as children transition through puberty, as well as evaluate the potential for reverse causality.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>25738596</pmid><doi>10.1289/ehp.1408417</doi><oa>free_for_read</oa></addata></record>
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ispartof Environmental health perspectives, 2015-06, Vol.123 (6), p.636-636
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source GreenFILE; Open Access: PubMed Central; ABI/INFORM Global (ProQuest); Publicly Available Content (ProQuest)
subjects Adipocytes
Adolescent
Adult
Age
Androgens
Body Mass Index
Body size (biology)
California - epidemiology
Child
Children
Children & youth
Children's Health
Chromatography
Disease control
Endocrine system
Environmental aspects
Environmental Exposure
Environmental Pollutants - blood
Estrogens
Ethers
Exposure
Female
Fire resistant materials
Flame retardants
Flame Retardants - metabolism
Furniture
Halogenated Diphenyl Ethers - blood
Health aspects
Health risk assessment
Humans
Lipids
Longitudinal Studies
Low income groups
Male
Mass spectrometry
Maternal Exposure
Medical laboratories
Medical screening
Metabolism
Mothers
Obesity
Obesity in children
Pesticides
Polybrominated biphenyls
Polybrominated diphenyl ethers
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Prenatal Exposure Delayed Effects - epidemiology
Prenatal influences
Risk factors
Scientific imaging
Serums
Studies
Thyroid gland
Womens health
Young Adult
title In utero and childhood polybrominated diphenyl ether exposures and body mass at age 7 years: the CHAMACOS study
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