HPV16 antibodies as risk factors for oropharyngeal cancer and their association with tumor HPV and smoking status

Highlights • Antibodies to the HPV16 proteome were measured in 256 cases of OPC and 250 controls. • Early gene Abs were detected in the sera of 85% of HPVOPC cases and 4% of controls. • Seropositivity is strongly associated with OPC risk (OR 249). • Seropositivity is associated with tumor HPV16 stat...

Full description

Saved in:
Bibliographic Details
Published in:Oral oncology 2015-07, Vol.51 (7), p.662-667
Main Authors: Anderson, Karen S, Dahlstrom, Kristina R, Cheng, Julia N, Alam, Rizwan, Li, Guojun, Wei, Qingyi, Gross, Neil D, Chowell, Diego, Posner, Marshall, Sturgis, Erich M
Format: Article
Language:English
Subjects:
Aged
Antibodies
Antibodies, Viral - genetics
Biomarker
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Head and neck cancer
Hematology, Oncology and Palliative Medicine
HPV
Human papillomavirus 16 - genetics
Humans
Immunoglobulin G - genetics
Logistic Models
Male
Middle Aged
Oropharyngeal cancer
Oropharyngeal Neoplasms - pathology
Oropharyngeal Neoplasms - virology
Otolaryngology
Risk Factors
Serology
Smoking - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Antibodies to the HPV16 proteome were measured in 256 cases of OPC and 250 controls. • Early gene Abs were detected in the sera of 85% of HPVOPC cases and 4% of controls. • Seropositivity is strongly associated with OPC risk (OR 249). • Seropositivity is associated with tumor HPV16 status.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2015.04.011