Epigenetics of Meningiomas

Meningiomas account for one-third of all adult central nervous system tumours and are divided into three WHO grades. In contrast to the relatively well characterized genetic alterations, our current understanding of epigenetic modifications involved in the meningioma-genesis and progression is rathe...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-6
Main Authors: Murnyak, Balazs, Bognar, Laszlo, Klekner, Almos, Hortobagyi, Tibor
Format: Article
Language:English
Subjects:
Biomedical research
Cancer
Cancer therapies
Cell Transformation, Neoplastic - genetics
Colleges & universities
Deoxyribonucleic acid
DNA
DNA methylation
DNA Methylation - genetics
Enzymes
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Gene expression
Genetic aspects
Humans
Meningioma
Meningioma - genetics
Meningioma - pathology
MicroRNAs
MicroRNAs - genetics
Neoplasm Recurrence, Local - genetics
Observations
Pathogenesis
Review
Tumorigenesis
Tumors
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Summary:Meningiomas account for one-third of all adult central nervous system tumours and are divided into three WHO grades. In contrast to the relatively well characterized genetic alterations, our current understanding of epigenetic modifications involved in the meningioma-genesis and progression is rather incomplete. Contrary to genetic alterations, epigenetic changes do not alter the primary DNA sequence and their reversible nature serves as an excellent basis for prevention and development of novel personalised tumour therapies. Indeed, growing body of evidence suggests that disturbed epigenetic regulation plays a key role in the pathogenesis of meningiomas. Altered DNA methylation, microRNA expression, histone, and chromatin modifications are frequently noted in meningiomas bearing prognostic and therapeutic relevance. In this review we provide an overview on recently identified epigenetic alterations in meningiomas and discuss their role in tumour initiation, progression, and recurrence.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/532451