Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabili...

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Bibliographic Details
Published in:Scientific reports 2015-06, Vol.5 (1), p.11199-11199, Article 11199
Main Authors: Zhang, Wei, Luo, Xiao-juan, Niu, Li-na, Yang, Hong-ye, Yiu, Cynthia K.Y., Wang, Tian-da, Zhou, Li-qun, Mao, Jing, Huang, Cui, Pashley, David H., Tay, Franklin R.
Format: Article
Language:English
Subjects:
101/28
631/61/2049/974
631/61/54/991
Animals
Biomimetic Materials - pharmacology
Biomimetics
Biomimetics - methods
Bone and Bones - metabolism
Calcium phosphates
Calcium Phosphates - pharmacology
Cells, Cultured
Collagen (type I)
Collagen Type I - metabolism
Controlled release
Crystallization - methods
Delayed-Action Preparations - pharmacology
Drug Carriers - pharmacology
Humanities and Social Sciences
Mineralization
multidisciplinary
Nanoparticles
Rats
Rats, Wistar
Remineralization
Science
Silica
Silicon Dioxide - pharmacology
Teeth
Tooth Remineralization
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Summary:Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep11199