Status of Superoxide Dismutase in Transfusion Dependent Thalassaemia

• Published in: North American journal of medical sciences 2015-05, Vol.7 (5), p.194-198
• Main Authors: Rujito, Lantip, Mulatsih, Sri, Sofro, Abdul Salam M
• Format: Article
• Language: English
• Subjects: Analysis; Anemia; Antioxidants (Nutrients); Care and treatment; Diagnosis; Health aspects; Original; Oxidative stress; Reactive oxygen species; Superoxides
• ISSN: 2250-1541; 1947-2714; 1947-2714
• DOI: 10.4103/1947-2714.157480

Thalassemia is a collection of genetic impairments in beta and alpha genes causing various states of anemia. Severe types of the disease need lifelong transfusions, leading to oxidant-antioxidant disturbance due to massive iron deposits. The aim of this study was to assess the antioxidant enzyme Superoxide Dismutase (SOD) and ferritin levels of thalassemia major patients in a peripheral health facility. Two hundred and nine probands were recruited and performed laboratory experiments for SOD and Ferritin levels. Chelation administration and clinical score were taken from interviewing the family and from medical report data. The study showed that SOD intensity was lower (162.41 u/ml) compared to the normal cutoff point (P = 0.001), while the mean of Ferritin levels was ten times over the normal value (4226,67 ng/dl). Observations also reported that chelation medicine was not administrated properly. The data indicates that thalassemic patients have oxidant-antioxidant uproar due to oxidative stress. Monitored chelating administration, selective antioxidant, and a well-balanced diet may prevent oxidative injury.