Determinants of Aortic Root Dilatation and Reference Values Among Young Adults Over a 20-Year Period: Coronary Artery Risk Development in Young Adults Study

Aortic size increases with age, but factors related to such dilatation in healthy young adult population have not been studied. We aim to evaluate changes in aortic dimensions and its principal correlates among young adults over a 20-year time period. Reference values for aortic dimensions in young...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-07, Vol.66 (1), p.23-29
Main Authors: Teixido-Tura, Gisela, Almeida, Andre L.C, Choi, Eui-Young, Gjesdal, Ola, Jacobs, David R, Dietz, Harry C, Liu, Kiang, Sidney, Stephen, Lewis, Cora E, Garcia-Dorado, David, Evangelista, Artur, Gidding, Samuel, Lima, João A.C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anthropometry
Aorta - diagnostic imaging
Aorta - growth & development
Aorta - pathology
Aortic Diseases - diagnostic imaging
Aortic Diseases - pathology
Asymptomatic Diseases
Coronary Disease - epidemiology
Coronary Disease - pathology
Dilatation, Pathologic - diagnostic imaging
Dilatation, Pathologic - pathology
Ethnicity
Female
Follow-Up Studies
Humans
Male
Reference Standards
Risk
Sex Characteristics
Ultrasonography
United States - epidemiology
Young Adult
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Summary:Aortic size increases with age, but factors related to such dilatation in healthy young adult population have not been studied. We aim to evaluate changes in aortic dimensions and its principal correlates among young adults over a 20-year time period. Reference values for aortic dimensions in young adults by echocardiography are also provided. Healthy Coronary Artery Risk Development in Young Adults (CARDIA) study participants aged 23 to 35 years in 1990–1991 (n=3051) were included after excluding 18 individuals with significant valvular dysfunction. Aortic root diameter (ARD) by M-mode echocardiography at year-5 (43.7% men; age, 30.2±3.6 years) and year-25 CARDIA exams was obtained. Univariable and multivariable analyses were performed to assess associations of ARD with clinical data at years-5 and -25. ARD from year-5 was used to establish reference values of ARD in healthy young adults. ARD at year-25 was greater in men (33.3±3.7 versus 28.7±3.4 mm; P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.115.05156