Determinants of Aortic Root Dilatation and Reference Values Among Young Adults Over a 20-Year Period: Coronary Artery Risk Development in Young Adults Study

Aortic size increases with age, but factors related to such dilatation in healthy young adult population have not been studied. We aim to evaluate changes in aortic dimensions and its principal correlates among young adults over a 20-year time period. Reference values for aortic dimensions in young...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-07, Vol.66 (1), p.23-29
Main Authors: Teixido-Tura, Gisela, Almeida, Andre L.C, Choi, Eui-Young, Gjesdal, Ola, Jacobs, David R, Dietz, Harry C, Liu, Kiang, Sidney, Stephen, Lewis, Cora E, Garcia-Dorado, David, Evangelista, Artur, Gidding, Samuel, Lima, João A.C
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anthropometry
Aorta - diagnostic imaging
Aorta - growth & development
Aorta - pathology
Aortic Diseases - diagnostic imaging
Aortic Diseases - pathology
Asymptomatic Diseases
Coronary Disease - epidemiology
Coronary Disease - pathology
Dilatation, Pathologic - diagnostic imaging
Dilatation, Pathologic - pathology
Ethnicity
Female
Follow-Up Studies
Humans
Male
Reference Standards
Risk
Sex Characteristics
Ultrasonography
United States - epidemiology
Young Adult
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container_issue 1
container_start_page 23
container_title Hypertension (Dallas, Tex. 1979)
container_volume 66
creator Teixido-Tura, Gisela
Almeida, Andre L.C
Choi, Eui-Young
Gjesdal, Ola
Jacobs, David R
Dietz, Harry C
Liu, Kiang
Sidney, Stephen
Lewis, Cora E
Garcia-Dorado, David
Evangelista, Artur
Gidding, Samuel
Lima, João A.C
description Aortic size increases with age, but factors related to such dilatation in healthy young adult population have not been studied. We aim to evaluate changes in aortic dimensions and its principal correlates among young adults over a 20-year time period. Reference values for aortic dimensions in young adults by echocardiography are also provided. Healthy Coronary Artery Risk Development in Young Adults (CARDIA) study participants aged 23 to 35 years in 1990–1991 (n=3051) were included after excluding 18 individuals with significant valvular dysfunction. Aortic root diameter (ARD) by M-mode echocardiography at year-5 (43.7% men; age, 30.2±3.6 years) and year-25 CARDIA exams was obtained. Univariable and multivariable analyses were performed to assess associations of ARD with clinical data at years-5 and -25. ARD from year-5 was used to establish reference values of ARD in healthy young adults. ARD at year-25 was greater in men (33.3±3.7 versus 28.7±3.4 mm; P
doi_str_mv 10.1161/HYPERTENSIONAHA.115.05156
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We aim to evaluate changes in aortic dimensions and its principal correlates among young adults over a 20-year time period. Reference values for aortic dimensions in young adults by echocardiography are also provided. Healthy Coronary Artery Risk Development in Young Adults (CARDIA) study participants aged 23 to 35 years in 1990–1991 (n=3051) were included after excluding 18 individuals with significant valvular dysfunction. Aortic root diameter (ARD) by M-mode echocardiography at year-5 (43.7% men; age, 30.2±3.6 years) and year-25 CARDIA exams was obtained. Univariable and multivariable analyses were performed to assess associations of ARD with clinical data at years-5 and -25. ARD from year-5 was used to establish reference values of ARD in healthy young adults. ARD at year-25 was greater in men (33.3±3.7 versus 28.7±3.4 mm; P&lt;0.001) and in whites (30.9±4.3 versus 30.5±4.1 mm; P=0.006). On multivariable analysis, ARD at year-25 was positively correlated with male sex, white ethnicity, age, height, weight, 20-year gain in weight, active smoking at baseline, and 20-year increase in diastolic, systolic, and mean arterial pressure. A figure showing the estimated 95th percentile of ARD by age and body surface area stratified by race and sex is provided. This study demonstrates that smoking, blood pressure, and increase in body weight are the main modifiable correlates of aortic root dilation during young adulthood. 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identifier ISSN: 0194-911X
ispartof Hypertension (Dallas, Tex. 1979), 2015-07, Vol.66 (1), p.23-29
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source Free E-Journal (出版社公開部分のみ）
subjects Adolescent
Adult
Anthropometry
Aorta - diagnostic imaging
Aorta - growth & development
Aorta - pathology
Aortic Diseases - diagnostic imaging
Aortic Diseases - pathology
Asymptomatic Diseases
Coronary Disease - epidemiology
Coronary Disease - pathology
Dilatation, Pathologic - diagnostic imaging
Dilatation, Pathologic - pathology
Ethnicity
Female
Follow-Up Studies
Humans
Male
Reference Standards
Risk
Sex Characteristics
Ultrasonography
United States - epidemiology
Young Adult
title Determinants of Aortic Root Dilatation and Reference Values Among Young Adults Over a 20-Year Period: Coronary Artery Risk Development in Young Adults Study
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