Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis

Long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA Sox2ot is up-regulated in some tumors. However, the contributions of Sox2ot to hepatocellular carcinoma (HCC) remain largely unknown. In the present study, expression of lncRNA Sox2ot...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2015-01, Vol.8 (4), p.4008-4014
Main Authors: Shi, Xiao-Min, Teng, Fei
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - secondary
Carcinoma, Hepatocellular - therapy
Cell Movement
Female
Gene Expression Regulation, Neoplastic
Hep G2 Cells
Humans
Kaplan-Meier Estimate
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Male
Middle Aged
Multivariate Analysis
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Original
Proportional Hazards Models
Retrospective Studies
Risk Factors
RNA Interference
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Time Factors
Transfection
Treatment Outcome
Up-Regulation
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Summary:Long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and the lncRNA Sox2ot is up-regulated in some tumors. However, the contributions of Sox2ot to hepatocellular carcinoma (HCC) remain largely unknown. In the present study, expression of lncRNA Sox2ot was evaluated by quantitative real-time PCR in tumor tissues and adjacent non-tumor tissues in 84 HCC patients. The association of lncRNA Sox2ot expression with clinicopathological features and the prognosis of HCC patients were also analyzed. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. Small interfering RNA assay was used to explore the function of lncRNA Sox2ot on HCC cell migration and invasion. lncRNA Sox2ot expression level was significantly higher in HCC tissues compared with adjacent non-tumor tissues (P
ISSN:1936-2625