Dendritic cells change IL-27 production pattern during childhood

Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described. In our present study we enrolled children (n = 55) in the range from 1 day of to 18 years of age a...

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Bibliographic Details
Published in:BMC research notes 2015-06, Vol.8 (1), p.232-232, Article 232
Main Authors: Meyer, Claudius U, Birkholz, Julia, Weins, Nadine, Doganci, Aysefa, Gehring, Stephan, Zepp, Fred, Knuf, Markus
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Aging - immunology
Analysis
Blood
Child
Child development
Child, Preschool
Dendritic cells
Dendritic Cells - cytology
Dendritic Cells - drug effects
Dendritic Cells - immunology
Dendritic Cells - metabolism
Development and progression
Disease susceptibility
Female
Gene Expression Regulation, Developmental - immunology
Health aspects
Humans
Infant
Infant, Newborn
Interferon-gamma - pharmacology
Interleukins
Interleukins - blood
Interleukins - genetics
Interleukins - immunology
Lipopolysaccharides - pharmacology
Male
Medical examination
Poly I-C - pharmacology
Primary Cell Culture
Puberty - immunology
Short Report
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Summary:Interleukin-27 (IL-27) has been described to be highly expressed during the very first days after birth, but secretion of IL-27 by dendritic cells during the course of childhood has not been described. In our present study we enrolled children (n = 55) in the range from 1 day of to 18 years of age and asked for a small whole blood sample. The capacity of dendritic cells to produce IL-27 during childhood was measured after whole blood culture with or without inflammatory stimuli. Results support recent findings of high IL-27 levels after birth and lowest levels in adults. Interestingly, we detected an interim peak production level at early adolescence. These data hint to prominent roles of IL-27 at the very start of post-natal life. Furthermore, a link has been given to so far not described immunological events during puberty.
ISSN:1756-0500
1756-0500
DOI:10.1186/s13104-015-1182-0