Matching of feedback inhibition with excitation ensures fidelity of information flow in the anterior piriform cortex

Highlights • Pyramidal cells in the piriform cortex fire 1–2 spikes per stimulus following varying stimuli applied to mitral cell axons. • The limited spike number is due to inhibition from fast-spiking cells in layer 3 that temporally tracks excitation. • Inhibition also limits spike number in a po...

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Bibliographic Details
Published in:Neuroscience 2014-09, Vol.275, p.519-530
Main Authors: Sheridan, D.C, Hughes, A.R, Erdélyi, F, Szabó, G, Hentges, S.T, Schoppa, N.E
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Female
Male
Mice
Mice, Transgenic
Neural Inhibition - physiology
Neurology
Neurons - physiology
Patch-Clamp Techniques
Piriform Cortex - physiology
Synaptic Transmission - physiology
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Summary:Highlights • Pyramidal cells in the piriform cortex fire 1–2 spikes per stimulus following varying stimuli applied to mitral cell axons. • The limited spike number is due to inhibition from fast-spiking cells in layer 3 that temporally tracks excitation. • Inhibition also limits spike number in a population of interneurons labeled in GAD65-eGFP mice. • The limited spike number in cortical cells could facilitate detection of incoming beta or gamma oscillations.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.06.033