Intraventricular cerebrospinal fluid temperature analysis using MR diffusion‐weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects

• Published in: Brain and behavior 2015-06, Vol.5 (6), p.e00340-n/a
• Main Authors: Sumida, Kaoru, Sato, Noriko, Ota, Miho, Sakai, Koji, Nippashi, Yasumasa, Sone, Daichi, Yokoyama, Kota, Ito, Kimiteru, Maikusa, Norihide, Imabayashi, Etsuko, Matsuda, Hiroshi, Yamada, Kei, Murata, Miho, Kunimatsu, Akira, Ohtomo, Kuni
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Atrophy; Body Temperature; Brain research; Cerebral Ventricles - pathology; Cerebral Ventricles - physiopathology; Cerebrospinal Fluid; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging - methods; diffusion‐weighted imaging thermometry; Drug dosages; Female; Humans; Male; Males; Middle Aged; multiple system atrophy; Multiple System Atrophy - cerebrospinal fluid; Multiple System Atrophy - diagnosis; Multiple System Atrophy - physiopathology; Organ Size; Original Research; Parkinson Disease - cerebrospinal fluid; Parkinson Disease - diagnosis; Parkinson Disease - physiopathology; Parkinson's disease; Reproducibility of Results; Sex Factors; Statistics as Topic; temperature; Thermometry - methods; Womens health
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.340

Purpose We examined the temperature of the intraventricular cerebrospinal fluid (Tv) in patients with Parkinson's disease (PD) and those with multiple system atrophy (MSA) in comparison with healthy subjects, and we examined normal changes in this temperature with aging. Methods Tv was estimated by magnetic resonance (MR) diffusion‐weighted imaging (DWI) thermometry in 36 PD patients (19 males, 17 females), 34 MSA patients (17 males, 17 females), 64 age‐matched controls (27 men, 37 women), and 114 all‐age adult controls (47 men, 67 women; 28–89 years old). The volume of lateral ventricles was also estimated using FreeSurfer in all subjects. Tv and ventricular volume data were compared among the PD and MSA patients and age‐matched controls. We also evaluated the relationship between Tv and age in the 114 all‐age controls, controlling for ventricular volume. Men and women were analyzed separately. Results The male PD and MSA patients had significantly higher Tv values compared to the male controls, with no significant difference in ventricular volume among them. There was no significant difference in Tv between the female patients and controls. In the all‐age male controls, there was a significant negative correlation between Tv and age controlling for ventricular volume, and this was not observed in the women. Conclusion DWI thermometry is a useful and easy method for demonstrating an altered intracranial environment in male patients and healthy controls, but not in females. DWI thermometry can thus be used to help to explore the pathophysiology of Parkinsonian syndromes and to differentiate individuals affected by neurodegenerative disease with autonomic dysfunction from those without it. Cerebrospinal fluid temperature was measured using diffusion‐weighted imaging. Decline of brain temperature with aging was demonstrated in men. The temperature of male patients with Parkinson's disease and multiple system atrophy was higher than that of normal controls.