Neuroticism modulates the effects of intranasal vasopressin treatment on the neural response to positive and negative social interactions

• Published in: Neuropsychologia 2015-07, Vol.73, p.108-115
• Main Authors: Feng, Chunliang, DeMarco, Ashley C., Haroon, Ebrahim, Rilling, James K.
• Format: Article
• Language: English
• Subjects: Administration, Intranasal; Adolescent; Anxiety Disorders - physiopathology; Anxiety Disorders - psychology; Brain - drug effects; Brain - physiopathology; Brain Mapping; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Cooperation; Double-Blind Method; Emotions - drug effects; Emotions - physiology; fMRI; Humans; Interpersonal Relations; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Neuroticism; Oxygen - blood; Oxytocin; Oxytocin - administration & dosage; Personality Tests; Prisoner Dilemma; Psychotropic Drugs - administration & dosage; Vasopressin; Vasopressins - administration & dosage; Young Adult
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2015.05.004

Neuroticism is a fundamental personality trait associated with proneness to feel negative affect. Here we ask how Neuroticism influences the neural response to positive and negative social interactions and how Neuroticism modulates the effect of intranasal oxytocin (OT) and vasopressin (AVP) on the neural response to social interactions. In a double-blind, placebo-controlled study, 153 male participants were randomized to receive 24IU intranasal OT, 20 IU AVP or placebo. Afterwards, they were imaged with fMRI while playing an iterated Prisoner's Dilemma Game. On a different day, subjects completed the NEO personality inventory to measure Neuroticism. Neuroticism was positively correlated with the neural response to negative social interactions in the anterior cingulate cortex/medial prefrontal cortex and with the neural response to positive social interactions in the insula, indicating that Neuroticism modulates neuropsychological processing of both negative and positive social interactions. Neuroticism did not modulate the effect of intranasal OT treatment on the neural response to either positive or negative social interactions. On the other hand, AVP treatment significantly interacted with Neuroticism to modulate the BOLD response to both positive and negative social interactions. Specifically, AVP increased anterior cingulate cortex/medial prefrontal cortex and lateral temporal lobe responses to negative social interactions to a greater extent in participants scoring high rather than low on Neuroticism. AVP also increased the insula response to positive social interactions to a greater extent in participants scoring high rather than low on Neuroticism. These results imply that AVP may increase emotion regulation in response to negative social interactions and the salience of positive social interactions to a greater extent in individuals high compared to low in Neuroticism. The current findings urge caution against uniform clinical application of nonapeptides and suggest that their efficacy may vary as a function of personality. •Investigate Neuroticism and neuropeptides modulation of brain activity.•Over 150 male subjects are studied.•Prisoner's Dilemma game is used to model everyday social interactions.•Neuroticism modulates the neural responses to positive and negative social events.•Modulatory effects of vasopressin depends on level of Neuroticism.