Visceral adiposity and left ventricular remodeling: The Multi-Ethnic Study of Atherosclerosis

• Published in: Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2015-07, Vol.25 (7), p.667-676
• Main Authors: Abbasi, S.A, Hundley, W.G, Bluemke, D.A, Jerosch-Herold, M, Blankstein, R, Petersen, Steffen E, Rider, Oliver J, Lima, J.A.C, Allison, M.A, Murthy, V.L, Shah, R.V
• Format: Article
• Language: English
• Subjects: Adipokines - metabolism; Aged; Atherosclerosis - pathology; Body Mass Index; Cardiac magnetic resonance imaging; Cardiovascular; Ethnic Groups; Female; Heart Ventricles - pathology; Humans; Intra-Abdominal Fat - pathology; Magnetic Resonance Imaging; Male; Middle Aged; Obesity; Obesity, Abdominal - ethnology; Remodeling; Stroke Volume; Subcutaneous Fat - pathology; Tomography, X-Ray Computed; United States; Ventricular Remodeling; Visceral adiposity
• ISSN: 0939-4753; 1590-3729
• DOI: 10.1016/j.numecd.2015.03.016

Abstract Background and aims Visceral fat (VF) is a source of pro-inflammatory adipokines implicated in cardiac remodeling. We sought to determine the impact of visceral fat and subcutaneous fat (SQ) depots on left ventricular (LV) structure, function, and geometry in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods and results We performed a post-hoc analysis on 1151 participants from MESA with cardiac magnetic resonance quantification of LV mass and LV mass-to-volume ratio (LVMV, an index of concentricity) and computed tomographic-derived SQ and VF area. Multivariable regression models to estimate association between height-indexed SQ and VF area (per cm2 /m) with height-indexed LV mass (per height2.7 ) and LVMV were constructed, adjusted for clinical, biochemical, and demographic covariates. We found that both VF and SQ area were associated with height-indexed LV mass (ρ = 0.36 and 0.12, P