Heterogeneity of Muscle Blood Flow and Metabolism: Influence of Exercise, Aging, and Disease States

The systematic increase in V˙O2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (Q˙O2)-to- V˙O2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased Q˙O2/V˙O2 heterogeneity can be judged as "...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2015-07, Vol.43 (3), p.117-124
Main Authors: Heinonen, Ilkka, Koga, Shunsaku, Kalliokoski, Kari K, Musch, Timothy I, Poole, David C
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Aging - physiology
Chronic Disease
Diabetes Mellitus - physiopathology
Exercise - physiology
Heart Failure - physiopathology
Humans
Muscle, Skeletal - blood supply
Muscle, Skeletal - physiology
Oxygen Consumption
Physical Education and Training
Regional Blood Flow
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Summary:The systematic increase in V˙O2 uptake and O2 extraction with increasing work rates conceals a substantial heterogeneity of O2 delivery (Q˙O2)-to- V˙O2 matching across and within muscles and other organs. We hypothesize that whether increased/decreased Q˙O2/V˙O2 heterogeneity can be judged as "good" or "bad," for example, after exercise training or in aged individuals or with disease (heart failure, diabetes) depends on the resultant effects on O2 transport and contractile performance.
ISSN:0091-6331
1538-3008
DOI:10.1249/JES.0000000000000044