Relationship of unilateral total hip arthroplasty (THA) to contralateral and ipsilateral knee joint degeneration – a longitudinal 3T MRI study from the Osteoarthritis Initiative (OAI)

SummaryObjectiveTo evaluate the association of prevalent unilateral total hip arthroplasty (THA) with worsening of degenerative knee abnormalities and clinical outcomes in the ipsilateral and contralateral knee. MethodsBoth knees of 30 individuals in the Osteoarthritis Initiative (OAI) with unilater...

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Published in:Osteoarthritis and cartilage 2015-07, Vol.23 (7), p.1144-1153
Main Authors: Jungmann, P.M, Nevitt, M.C, Baum, T, Liebl, H, Nardo, L, Liu, F, Lane, N.E, McCulloch, C.E, Link, T.M
Format: Article
Language:English
Subjects:
Aged
Arthroplasty, Replacement, Hip - adverse effects
Cartilage
Case-Control Studies
Disease Progression
Female
Hip arthroplasty
Humans
Isometric Contraction - physiology
Knee
Knee Joint - physiopathology
Longitudinal Studies
Magnetic Resonance Imaging - methods
Male
Middle Aged
Osteoarthritis
Osteoarthritis, Knee - diagnosis
Osteoarthritis, Knee - etiology
Osteoarthritis, Knee - physiopathology
Rheumatology
Severity of Illness Index
T2 measurements
WORMS
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Summary:SummaryObjectiveTo evaluate the association of prevalent unilateral total hip arthroplasty (THA) with worsening of degenerative knee abnormalities and clinical outcomes in the ipsilateral and contralateral knee. MethodsBoth knees of 30 individuals in the Osteoarthritis Initiative (OAI) with unilateral THA ( n = 14 left, n = 16 right) at baseline were assessed at baseline and at 4-year follow-up for Whole-organ MR Imaging Scores (WORMS), cartilage T 2 relaxation times (only available for right knees), Western Ontario and McMasters Universities Arthritis Index (WOMAC) scores and upper leg isometric strength. Right knees of 30 individuals without THA were analyzed as controls. Contralateral knees were compared to ipsilateral knees with paired t-tests and to control knees with multivariate regression analysis adjusting for covariates. ResultsIn paired analyses, compared to ipsilateral knees, contralateral knees had higher WORMS total ( P = 0.008) and cartilage scores ( P = 0.007) at baseline. Over 4 years contralateral knees worsened more on WORMS total score ( P = 0.008). Cartilage T 2 values were higher in knees contralateral to the THA (baseline, P = 0.02; follow-up, P 
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2015.03.022