Thiamine as a metabolic resuscitator in septic shock: a randomized, double-blind, placebo-controlled, pilot trial

The objective was to determine whether the administration of thiamine mitigates elevated lactate levels in patients with septic shock. Thiamine is essential for aerobic metabolism and we have found that thiamine levels are low and inversely correlated with lactate levels in patients with sepsis.

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Published in:Critical care (London, England) England), 2015-01, Vol.19 (S1), p.P392-P392, Article P392
Main Authors: Donnino, M, Andersen, LW, Chase, M, Berg, KM, Giberson, TA, Smithline, H, Tidswell, M, Wolfe, R, Cocchi, M
Format: Article
Language:English
Subjects:
Double-blind studies
Evidence-based medicine
Mortality
Poster Presentation
Sepsis
Vitamin B
Vitamin deficiency
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cited_by cdi_FETCH-LOGICAL-c1862-12fbce575e2364a414b80a17d0d1d29c78e27d466e5b4feda6441f9523065cdd3
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container_end_page P392
container_issue S1
container_start_page P392
container_title Critical care (London, England)
container_volume 19
creator Donnino, M
Andersen, LW
Chase, M
Berg, KM
Giberson, TA
Smithline, H
Tidswell, M
Wolfe, R
Cocchi, M
description The objective was to determine whether the administration of thiamine mitigates elevated lactate levels in patients with septic shock. Thiamine is essential for aerobic metabolism and we have found that thiamine levels are low and inversely correlated with lactate levels in patients with sepsis.
doi_str_mv 10.1186/cc14472
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ispartof Critical care (London, England), 2015-01, Vol.19 (S1), p.P392-P392, Article P392
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1364-8535
1366-609X
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source Publicly Available Content Database; PubMed Central
subjects Double-blind studies
Evidence-based medicine
Mortality
Poster Presentation
Sepsis
Vitamin B
Vitamin deficiency
title Thiamine as a metabolic resuscitator in septic shock: a randomized, double-blind, placebo-controlled, pilot trial
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