Rapid and early α-fetoprotein and des-γ-carboxy prothrombin responses to initial arterial infusion chemotherapy predict treatment outcomes of advanced hepatocellular carcinoma

The aim of the present study was to predict the effects of transarterial infusion (TAI) chemotherapy based on early changes in α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) in patients with advanced hepatocellular carcinoma (HCC). Seventy-four patients who underwent TAI with cisplatin, 5-f...

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Bibliographic Details
Published in:Molecular and clinical oncology 2015-05, Vol.3 (3), p.655-662
Main Authors: OYAMA, KENJI, KODA, MASAHIKO, SUGIHARA, TAKAAKI, KISHINA, MANABU, MIYOSHI, KENICHI, OKAMOTO, TOSHIAKI, HODOTSUKA, MASANORI, FUJISE, YUKI, MATONO, TOMOMITSU, TOKUNAGA, SHIHO, OKAMOTO, KINYA, HOSHO, KEIKO, OKANO, JUNICHI, MURAWAKI, YOSHIKAZU
Format: Article
Language:English
Subjects:
Analysis
Biomarkers
Blood clots
Cancer
Cancer therapies
Care and treatment
Chemotherapy
des-γ-carboxy prothrombin
Diagnosis
Hepatitis
hepatocellular carcinoma
Hepatoma
Japan
Liver cancer
Medical prognosis
Metastasis
Mortality
Oncology
Response rates
Studies
transarterial infusion chemotherapy
treatment response
Tumors
Veins & arteries
α-fetoprotein
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Summary:The aim of the present study was to predict the effects of transarterial infusion (TAI) chemotherapy based on early changes in α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP) in patients with advanced hepatocellular carcinoma (HCC). Seventy-four patients who underwent TAI with cisplatin, 5-fluorouracil, mitomycin C and epirubicin for advanced HCC were enrolled. Antitumor responses were evaluated 6 months after TAI. Rapid and early responses were defined as the ratio of AFP or DCP after 1 week and 1 month compared to baseline. A total of 5, 10, 17 and 42 patients had complete response (CR), partial response (PR), stable disease (SD) or progressive disease (PD), respectively. Early AFP response was significantly lower in the CR+PR compared to the SD+PD groups (P
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2015.523