Expression of signal transducer and activator of transcription 3 and its phosphorylated form is significantly upregulated in patients with papillary thyroid cancer

The aim of the present study was to investigate the expression of signal transducer and activator of transcription 3 (STAT3) and phosphorylated STAT3 (pSTAT3) in tissues of papillary thyroid cancer (PTC) in comparison with the expression in adjacent normal tissues. The expression of STAT3, pSTAT3, f...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2015-06, Vol.9 (6), p.2195-2201
Main Authors: YAN, LI, LI, LI, LI, QINGHUAI, DI, WANG, SHEN, WEI, ZHANG, LINLEI, GUO, HAO
Format: Article
Language:English
Subjects:
Angiogenesis
Cancer
FGF2
Fibroblasts
Immunoglobulins
Lymphatic system
Metastasis
Oncology, Experimental
papillary thyroid cancer
pSTAT3
Rodents
STAT3
Thyroid cancer
Tumors
Vascular endothelial growth factor
VEGF-C
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Summary:The aim of the present study was to investigate the expression of signal transducer and activator of transcription 3 (STAT3) and phosphorylated STAT3 (pSTAT3) in tissues of papillary thyroid cancer (PTC) in comparison with the expression in adjacent normal tissues. The expression of STAT3, pSTAT3, fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor-C (VEGF-C) was examined in tissues of 42 cases of PTC and the adjacent normal tissues of 20 of the 42 PTC cases using immunohistochemistry and western blotting. The association between the expression levels and the clinicopathological features was analyzed. The expression of STAT3, pSTAT3, FGF2 and VEGF-C in the PTC tissues (76.2, 42.9, 81.0 and 73.8%, respectively) was significantly higher than that in the normal tissues (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2015.2409