Human Plasmacytoid Dendritic Cells Elicited Different Responses after Infection with Pathogenic and Nonpathogenic Junin Virus Strains

The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susc...

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Bibliographic Details
Published in:Journal of virology 2015-07, Vol.89 (14), p.7409-7413
Main Authors: Negrotto, Soledad, Mena, Hebe A, Ure, Agustin E, Jaquenod De Giusti, Carolina, Bollati-Fogolín, Mariela, Vermeulen, Elba M, Schattner, Mirta, Gómez, Ricardo M
Format: Article
Language:English
Subjects:
Arenavirus
Cell Differentiation
Cell Survival
Cellular Response to Infection
Cytokines - biosynthesis
Dendritic Cells - immunology
Dendritic Cells - virology
Humans
Junin virus
Junin virus - immunology
Junin virus - pathogenicity
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Summary:The arenavirus Junin virus (JUNV) is the etiologic agent of Argentine hemorrhagic fever. We characterized the JUNV infection of human peripheral blood-derived plasmacytoid dendritic cells (hpDC), demonstrating that hpDC are susceptible to infection with the C#1 strain (attenuated) and even more susceptible to infection with the P (virulent) JUNV strain. However, hpDC elicited different responses in terms of viability, activation, maturation, and cytokine expression after infection with both JUNV strains.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.01014-15