Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

Liposarcoma has previously been described in Western studies, however, such cases are rarely reported in the mediastinum. In addition, the presence of a liposarcoma with smooth muscle and neural differentiation has not been previously reported. Thus, the present study describes the rare case of a 28...

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Bibliographic Details
Published in:Oncology letters 2015-06, Vol.9 (6), p.2667-2669
Main Authors: MA, JIAN, ZHANG, HONG-MEI, ZHANG, LI-WANG, ZHENG, MIN-WEN, YU, MIN
Format: Article
Language:English
Subjects:
Adipocytes
Antigens
Care and treatment
Case reports
Cell differentiation
Development and progression
differentiation
Dyspnea
Health aspects
Liposarcoma
mediastinum
Medical prognosis
neural
Oncology
Ostomy
Patients
Smooth muscle
Surgery
Tumors
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Summary:Liposarcoma has previously been described in Western studies, however, such cases are rarely reported in the mediastinum. In addition, the presence of a liposarcoma with smooth muscle and neural differentiation has not been previously reported. Thus, the present study describes the rare case of a 28-year-old Chinese male admitted to our hospital with the symptoms of chest tightness and shortness of breath due to a recurrent fibrolipoma in the mediastinum. The resected tumor measured 23 cm at its largest diameter, with histopathological and immunohistochemical features indicating a well-differentiated liposarcoma accompanied by smooth muscle and neural differentiation. Following the resection, the patient underwent radiation treatment and remains alive with no evidence of disease recurrence at two months post-surgery. To the best of our knowledge, the present study is the first to report a case of liposarcoma with smooth muscle and neural differentiation, which indicates that liposarcomas could potentially originate from stem cells. The present study highlights the fact that pathologists must carefully investigate the histopathological characteristics of liposarcomas in order to obtain an accurate diagnosis.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.3103