The Protective Effect of Puerarin on Myocardial Infarction Reperfusion Injury (MIRI): A Meta-Analysis of Randomized Studies in Rat Models

Although puerarin is generally considered as a protective agent for cardio-cerebrovascular diseases, the exact effect on reducing myocardial infarction reperfusion injury (MIRI) is not well understood. This study aimed to pool previous randomized controlled studies based on rat models to evaluate th...

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Bibliographic Details
Published in:Medical science monitor 2015-06, Vol.21, p.1700-1706
Main Authors: Wenjun, Huang, Jing, Wen, Tao, Li, Ling, Mao, Yan, Yang, Xiaorong, Zeng, Rui, Zhou
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Isoflavones - pharmacology
Meta-Analysis
Myocardial Infarction - prevention & control
Myocardial Ischemia - prevention & control
Myocardial Reperfusion Injury - blood
Myocardial Reperfusion Injury - prevention & control
Protective Agents - pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
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Summary:Although puerarin is generally considered as a protective agent for cardio-cerebrovascular diseases, the exact effect on reducing myocardial infarction reperfusion injury (MIRI) is not well understood. This study aimed to pool previous randomized controlled studies based on rat models to evaluate the effects of puerarin on MIRI. Relevant studies were searched among PubMed, Embase, Medline, and CNKI (China National Knowledge Infrastructure). To assess the therapeutic effects of protective effects of puerarin on myocardial infarction reperfusion injury, the outcome indicators which were reported in at least 3 original studies were extracted and pooled, including size of myocardial ischemia (MIS) and myocardial infarction (MIN), creatine kinase (CK), methylene dioxyamphetamine (MDA), and superoxide dismutase (SOD). Administration of puerarin could effectively reduce the size of MIN after MIR (mean difference: -29.20, 95%CI: -44.90 to -13.51, p=0.0003). Puerarin directly led to decreased CK (mean difference: -6.89, 95%CI: -9.40 to -4.38, p=0.00001) and MDA (mean difference: -2.41, 95%CI: -3.14 to -1.68, p
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/msm.894312