A single amino acid deletion in the matrix protein of porcine reproductive and respiratory syndrome virus confers resistance to a polyclonal swine antibody with broadly neutralizing activity

Assessment of virus neutralization (VN) activity in 176 pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) identified one pig with broadly neutralizing activity. A Tyr-10 deletion in the matrix protein provided escape from broad neutralization without affecting homologous...

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Bibliographic Details
Published in:Journal of virology 2015-06, Vol.89 (12), p.6515-6520
Main Authors: Trible, Benjamin R, Popescu, Luca N, Monday, Nicholas, Calvert, Jay G, Rowland, Raymond R R
Format: Article
Language:English
Subjects:
Animals
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Molecular Sequence Data
Pathogenesis and Immunity
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - immunology
Sequence Analysis, DNA
Sequence Deletion
Swine
Tyrosine - genetics
Viral Matrix Proteins - genetics
Viral Matrix Proteins - immunology
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Summary:Assessment of virus neutralization (VN) activity in 176 pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV) identified one pig with broadly neutralizing activity. A Tyr-10 deletion in the matrix protein provided escape from broad neutralization without affecting homologous neutralizing activity. The role of the Tyr-10 deletion was confirmed through an infectious clone with a Tyr-10 deletion. The results demonstrate differences in the properties and specificities of VN responses elicited during PRRSV infection.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.03287-14