Inter-Pregnancy Intervals and the Risk of Autism Spectrum Disorder: Results of a Population-Based Study

Recent studies have reported an increased risk of autism among second-born children conceived 36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship b...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2015-07, Vol.45 (7), p.2056-2066
Main Authors: Durkin, Maureen S., DuBois, Lindsay A., Maenner, Matthew J.
Format: Article
Language:English
Subjects:
Analysis
Autism
Autism Spectrum Disorder - etiology
Autism Spectrum Disorders
Behavioral Science and Psychology
Birth Intervals
Care and treatment
Child
Child and School Psychology
Complications and side effects
Female
Humans
Intervals
Male
Neurosciences
Original Paper
Pediatrics
Pervasive Developmental Disorders
Pregnancy
Pregnancy complications
Psychology
Public Health
Risk
Risk Factors
Sentinel surveillance
Siblings
Wisconsin
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Summary:Recent studies have reported an increased risk of autism among second-born children conceived 36 months after the birth of a sibling. Confirmation of this finding would point to inter-pregnancy interval (IPI) as a potentially modifiable risk factor for autism. This study evaluated the relationship between IPI and autism spectrum disorder (ASD) risk in a Wisconsin birth cohort of 31,467 second-born children, of whom 160 resided in the study area and were found to have ASD at age 8 years. In adjusted analyses, both short (84 month) IPIs were associated with a two-fold risk of ASD relative to IPIs of 24–47 months ( p  
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-015-2368-y