Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis

Resting-state functional magnetic resonance imaging (RS FMRI) has been widely used to analyze functional alterations in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) patients. Although many clinical studies of aMCI and AD patients using RS FMRI have been undertaken, conducti...

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Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-12
Main Authors: Na, Duk L., Seo, Sang Won, Jo, Hang Joon, Hwang, Jung-Min, Cha, Jungho, Lee, Jong-Min
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alterations
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - physiopathology
Alzheimer's disease
Amnesia - diagnostic imaging
Amnesia - physiopathology
Assessments
Brain
Brain - diagnostic imaging
Brain - physiopathology
Cognitive ability
Connectome
Diagnosis
Female
Fourier transforms
Homogeneity
Humans
Impairment
Magnetic fields
Magnetic Resonance Imaging
Male
Meta-analysis
Methods
Middle Aged
Patients
Physiology
Radiography
Regions
Rest
Software
Time series
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Lee, Jong-Min
description Resting-state functional magnetic resonance imaging (RS FMRI) has been widely used to analyze functional alterations in amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease (AD) patients. Although many clinical studies of aMCI and AD patients using RS FMRI have been undertaken, conducting a meta-analysis has not been easy because of seed selection bias by the investigators. The purpose of our study was to investigate the functional differences in aMCI and AD patients compared with healthy subjects in a meta-analysis. Thus, a multimethod approach using regional homogeneity, amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and global brain connectivity was used to investigate differences between three groups based on previously published data. According to the choice of RS FMRI approach used, the patterns of functional alteration were slightly different. Nevertheless, patients with aMCI and AD displayed consistently decreased functional characteristics with all approaches. All approaches showed that the functional characteristics in the left parahippocampal gyrus were decreased in AD patients compared with healthy subjects. Although some regions were slightly different according to the different RS FMRI approaches, patients with aMCI and AD showed a consistent pattern of decreased functional characteristics with all approaches.
doi_str_mv 10.1155/2015/907464
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subjects Aged
Aged, 80 and over
Alterations
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - physiopathology
Alzheimer's disease
Amnesia - diagnostic imaging
Amnesia - physiopathology
Assessments
Brain
Brain - diagnostic imaging
Brain - physiopathology
Cognitive ability
Connectome
Diagnosis
Female
Fourier transforms
Homogeneity
Humans
Impairment
Magnetic fields
Magnetic Resonance Imaging
Male
Meta-analysis
Methods
Middle Aged
Patients
Physiology
Radiography
Regions
Rest
Software
Time series
title Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis
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