Pretrial hippocampal θ-state differentiates single-unit response profiles during rabbit trace eyeblink conditioning

Eyeblink conditioning given in the explicit presence of hippocampal θ results in accelerated learning and enhanced multiple-unit responses, with slower learning and suppression of unit activity under non-θ conditions. Recordings from putative pyramidal cells during θ-contingent training show that pr...

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Bibliographic Details
Published in:Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2015-07, Vol.22 (7), p.318-322
Main Authors: Cicchese, Joseph J, Darling, Ryan D, Berry, Stephen D
Format: Article
Language:English
Subjects:
Action Potentials
Animals
Brief Communication
CA1 Region, Hippocampal - physiology
Conditioning, Eyelid - physiology
Neurons - physiology
Rabbits
Theta Rhythm - physiology
Time Factors
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Summary:Eyeblink conditioning given in the explicit presence of hippocampal θ results in accelerated learning and enhanced multiple-unit responses, with slower learning and suppression of unit activity under non-θ conditions. Recordings from putative pyramidal cells during θ-contingent training show that pretrial θ-state is linked to the probability of firing increases versus decreases rather than to the magnitude of such responses. These findings suggest that the learning facilitation during θ may be due to the recruitment of additional neurons that increase their firing rate during trials.
ISSN:1549-5485
1072-0502
1549-5485
DOI:10.1101/lm.038216.115