Electrodeposited silk coatings for bone implants

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2015-11, Vol.103 (8), p.1602-1609
• Main Authors: Elia, Roberto, Michelson, Courtney D., Perera, Austin L., Brunner, Teresa F., Harsono, Masly, Leisk, Gray G., Kugel, Gerard, Kaplan, David L.
• Format: Article
• Language: English
• Subjects: bioactive coating; Biomedical materials; Bone Substitutes - chemistry; dental implant coating; Electrochemical Techniques; electrodeposition; electrogelation; Materials research; Materials science; Materials Testing; Prostheses and Implants; Silk - chemistry
• ISSN: 1552-4973; 1552-4981
• DOI: 10.1002/jbm.b.33351

The aim of this study was to characterize the mechanical properties and drug elution features of silk protein-based electrodeposited dental implant coatings. Silk processing conditions were modified to obtain coatings with a range of mechanical properties on titanium studs. These coatings were assessed for adhesive strength and dissolution, with properties tuned using water vapor annealing or glycerol incorporation to modulate crystalline content. Coating reproducibility was demonstrated over a range of silk concentrations from 1% to 10%. Surface roughness of titanium substrates was altered using industry relevant acid etching and grit blasting, and the effect of surface topography on silk coating adhesion was assessed. Florescent compounds were incorporated into the silk coatings, which were modulated for crystalline content, to achieve four days of sustained release of the compounds. This silk electrogelation technique offers a safe and relatively simple approach to generate mechanically robust, biocompatible, and degradable implant coatings that can also be functionalized with bioactive compounds to modulate the local regenerative tissue environment.