Current Concepts of Follicle-Stimulating Hormone Receptor Gene Regulation1

Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and granulosa cells of the ovary. Th...

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Bibliographic Details
Published in:Biology of reproduction 2011-01, Vol.84 (1), p.7-17
Main Authors: George, Jitu W, Dille, Elizabeth A, Heckert, Leslie L
Format: Article
Language:English
Subjects:
distal regulatory regions
follicle-stimulating hormone
follicle-stimulating hormone receptor
FSHR
gene regulation
gonadotropin receptors
granulosa cells
Minireview
pituitary hormones
Sertoli cells
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Summary:Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral component of the endocrine axis that regulates gonadal function and fertility. To transmit its signal, FSH must bind to its receptor (FSHR) located on Sertoli cells of the testis and granulosa cells of the ovary. Thus, both the magnitude and the target of hormone response are controlled by mechanisms that determine FSHR levels and cell-specific expression, which are supported by transcription of its gene. The present review examines the status of FSHR/Fshr gene regulation, emphasizing the importance of distal sequences in FSHR/Fshr transcription, new insights gained from the influx of genomics data and bioinformatics, and emerging trends that offer direction in deciphering the FSHR/Fshr regulatory landscape.
ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod.110.085043