Importance of lipid accumulation product index as a marker of CVD risk in PCOS women

The polycystic ovary syndrome (PCOS) is considered the most common endocrine disease during the woman's reproductive life, with prevalence ranging from 5 to 10% of women of reproductive age. There is a paucity of studies regarding the use of the lipid accumulation product (LAP) as a risk marker...

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Bibliographic Details
Published in:Lipids in health and disease 2015-06, Vol.14 (1), p.62-62, Article 62
Main Authors: Nascimento, Joelma Ximenes Prado Teixeira, Chein, Maria Bethânia da Costa, de Sousa, Rosângela Maria Lopes, Ferreira, Alexsandro dos Santos, Navarro, Paula Andrea, Brito, Luciane Maria Oliveira
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - metabolism
Cardiovascular Diseases - complications
Cardiovascular Diseases - metabolism
Demography
Female
Humans
Lipid Accumulation Product
Logistic Models
Physiological aspects
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - metabolism
Risk Factors
ROC Curve
Stein-Leventhal syndrome
Type 2 diabetes
Young Adult
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Summary:The polycystic ovary syndrome (PCOS) is considered the most common endocrine disease during the woman's reproductive life, with prevalence ranging from 5 to 10% of women of reproductive age. There is a paucity of studies regarding the use of the lipid accumulation product (LAP) as a risk marker for the development of cardiovascular disease (CVD). A cross-sectional study was conducted on 78 women aged 18 to 42 years seen at University Hospital of Maranhão, with a diagnosis of polycystic ovary syndrome according to the Rotterdam criteria. The following variables of interest were recorded on a protocol form: sociodemographic and behavioral data, body mass index, waist circumference, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol, high-density lipoprotein cholesterol, and systolic and diastolic blood pressure. Logistic regression showed that, except for HDL, all cardiovascular risk markers presented a higher chance of being altered when the lipid accumulation product was above the cut off value of 37.9 cm.mmol/L. The lipid accumulation product seems to be sufficient to indicate a risk of cardiovascular diseases in women with polycystic ovary syndrome.
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-015-0061-y