Prognostic role of copeptin after stroke: A systematic review and meta-analysis of observational studies

Copeptin, the C-terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke us...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2015-06, Vol.5 (1), p.11665-11665, Article 11665
Main Authors: Choi, Kyu-Sun, Kim, Hyun Jung, Chun, Hyoung-Joon, Kim, Jae Min, Yi, Hyeong-Joong, Cheong, Jin-Hwan, Kim, Choong-Hyun, Oh, Suck-Jun, Ko, Yong, Kim, Young-Soo, Bak, Koang-Hum, Ryu, Je-Il, Kim, Wonhee, Lim, Taeho, Ahn, Hyeong sik, Ahn, Il Min, Lee, Seon-Heui
Format: Article
Language:English
Subjects:
692/53/2422
692/617/375/534
Glycopeptides - blood
Humanities and Social Sciences
Humans
multidisciplinary
Observational Studies as Topic
Odds Ratio
Prognosis
Science
Stroke - blood
Stroke - diagnosis
Stroke - mortality
Stroke - therapy
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Copeptin, the C-terminal part of provasopressin, has emerged as a novel prognostic marker after hemorrhagic or ischemic stroke. The aim of this study was to quantitatively assess the prognostic significance of plasma copeptin level on functional outcome and mortality in patients with acute stroke using a meta-analysis of the available evidence. Thirteen relevant studies from 2,746 patients were finally included in our study. An elevated plasma copeptin level was associated with an increased risk of unfavorable outcome and mortality after stroke (OR 1.77; 95% CI, 1.44–2.19 and OR 3.90; 95% CI 3.07–4.95, respectively). The result of the pooled measure on standardized mean difference (SMD) was that plasma copeptin levels were found to be significantly higher in patients who died compared to survivors (SMD 1.70; 95% CI, 1.36–2.03). A stratified analysis by study region showed significant differences in SMD of copeptin and the heterogeneity among studies was significantly decreased. However, the positive association of copeptin with poor prognosis after stroke was consistent in each stratified analysis. The present meta-analysis suggests that early measurement of plasma copeptin could provide better prognostic information about functional outcome and mortality in patients with acute stroke.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep11665