Ductal Carcinoma In Situ of the Breast

Ductal carcinoma in situ (DCIS) of the breast is a potentially invasive neoplasm. Risk factors include high estrogen states such as use of oral contraceptive (OC) pills, nulliparity, advanced age at first birth, and also family history and genetic mutations. The incidence of this usually clinically...

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Bibliographic Details
Published in:Indian journal of surgery 2015-04, Vol.77 (2), p.141-146
Main Authors: Vaidya, Yash, Vaidya, Pradeep, Vaidya, Tanvi
Format: Article
Language:English
Subjects:
Breast cancer
Cardiac Surgery
Medicine
Medicine & Public Health
Neurosurgery
Pediatric Surgery
Plastic Surgery
Review
Review Article
Surgery
Thoracic Surgery
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Summary:Ductal carcinoma in situ (DCIS) of the breast is a potentially invasive neoplasm. Risk factors include high estrogen states such as use of oral contraceptive (OC) pills, nulliparity, advanced age at first birth, and also family history and genetic mutations. The incidence of this usually clinically silent condition has risen in the past few decades due to widespread screening and diagnostic mammography, with final diagnosis confirmed by biopsy. At present, treatment options include total or simple mastectomy or lumpectomy with radiation. Adjuvant therapy includes antiestrogens like tamoxifen and human epidermal growth factor receptor 2 (HER2) suppression therapy. With the latest advances in chemotherapy and better understanding on the pathogenesis of the lesion, it is anticipated that more effective modalities of treatment may soon be available.
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-013-0987-0