BRAF gene: From human cancers to developmental syndromes

The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade i...

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Bibliographic Details
Published in:Saudi journal of biological sciences 2015-07, Vol.22 (4), p.359-373
Main Authors: Hussain, Muhammad Ramzan Manwar, Baig, Mukhtiar, Mohamoud, Hussein Sheik Ali, Ulhaq, Zaheer, Hoessli, Daniel C., Khogeer, Ghaidaa Siraj, Al-Sayed, Ranem Radwan, Al-Aama, Jumana Yousuf
Format: Article
Language:English
Subjects:
BRAF gene
Cancer
Cancers
Developmental disabilities
Developmental syndromes
Genetic aspects
RAS–RAF overactivation
Review
الجوانب الوراثية
السرطان
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Summary:The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes—Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.
ISSN:1319-562X
2213-7106
DOI:10.1016/j.sjbs.2014.10.002