Cluster of differentiation 96 as a leukemia stem cell-specific marker and a factor for prognosis evaluation in leukemia

Resistance to chemotherapy is a major challenge for leukemia treatment. It has been suggested that leukemia stem cells (LSCs), a small pool of self-renewing leukemic cells, play important roles in development of chemotherapy resistance. The expression of cluster of differentiation 96 (CD96), a poten...

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Bibliographic Details
Published in:Molecular and clinical oncology 2015-07, Vol.3 (4), p.833-838
Main Authors: DU, WEN, HU, YANJIE, LU, CONG, LI, JUAN, LIU, WEI, HE, YANLI, WANG, PING, CHENG, CHEN, HU, YU, HUANG, SHIANG, YAO, JUNXIA, ZHENG, JIN'E
Format: Article
Language:English
Subjects:
acute leukemia
Cancer
Cancer therapies
Chemotherapy
cluster of differentiation 96
Comparative analysis
Cytotoxicity
Health aspects
Immunoglobulins
Leukemia
leukemia stem cells
Medical prognosis
minimal residual disease
Oncology
Patients
Population
prognosis
Stem cells
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Summary:Resistance to chemotherapy is a major challenge for leukemia treatment. It has been suggested that leukemia stem cells (LSCs), a small pool of self-renewing leukemic cells, play important roles in development of chemotherapy resistance. The expression of cluster of differentiation 96 (CD96), a potential marker for LSCs, was investigated in CD34+CD38− cells of 105 acute leukemia (AL) patients by flow cytometry. The data showed that all the CD34+, CD34+CD38− and CD34+CD38−CD96+ proportions were much higher in AL compared to the normal control (P15% CD34+CD38− cells achieved complete remission (CR), suggesting that as an LSC-rich population, the amount of CD34+CD38− cells may not be positively associated with the proportion of refractory LSCs. The mean percentage of the co-presence of CD96 expression itself was similar in AML patients with CR and non-CR (P>0.05). However, the CR rate was significantly higher in the AML population with
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2015.552