Antimicrobial Activity of the Essential Oil of Plectranthus neochilus against Cariogenic Bacteria

This work used the broth microdilution method to investigate the antimicrobial activity of the essential oil obtained from the leaves of Plectranthus neochilus (PN-EO) against a representative panel of oral pathogens. We assessed the antimicrobial activity of this oil in terms of the minimum inhibit...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2015-01, Vol.2015 (2015), p.1-6
Main Authors: Crotti, Antônio Eduardo Miller, Cunha, Wilson Roberto, Groppo, Milton, Dias, Herbert Júnior, Caixeta, Soraya Carolina, Crevelin, Eduardo José, Martins, C. H. G.
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Bacterial infections
Care and treatment
Chromatography
Dental caries
Enterococcus faecalis
Essences and essential oils
Fluorides
Health aspects
Lactobacillus casei
Lamiaceae
Microorganisms
Oils & fats
Plectranthus
Retention
Streptococcus mitis
Streptococcus mutans
Streptococcus sanguinis
Streptococcus sobrinus
Studies
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Summary:This work used the broth microdilution method to investigate the antimicrobial activity of the essential oil obtained from the leaves of Plectranthus neochilus (PN-EO) against a representative panel of oral pathogens. We assessed the antimicrobial activity of this oil in terms of the minimum inhibitory concentration (MIC). PN-EO displayed moderate activity against Enterococcus faecalis (MIC = 250 μg/mL) and Streptococcus salivarus (MIC = 250 μg/mL), significant activity against Streptococcus sobrinus (MIC = 62.5 μg/mL), Streptococcus sanguinis (MIC = 62.5 μg/mL), Streptococcus mitis (MIC = 31.25 μg/mL), and Lactobacillus casei (MIC = 31.25 μg/mL), and interesting activity against Streptococcus mutans (MIC = 3.9 μg/mL). GC-FID and GC-MS helped to identify thirty-one compounds in PN-EO; α-pinene (1, 14.1%), β-pinene (2, 7.1%), trans-caryophyllene (3, 29.8%), and caryophyllene oxide (4, 12.8%) were the major chemical constituents of this essential oil. When tested alone, compounds 1, 2, 3, and 4 were inactive (MIC > 4000 μg/mL) against all the microorganisms. These results suggested that the essential oil extracted from the leaves of Plectranthus neochilus displays promising activity against most of the evaluated cariogenic bacteria, especially S. mutans.
ISSN:1741-427X
1741-4288
DOI:10.1155/2015/102317