Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players

The physiologic stress induced by physical activity is reflected in immune system perturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in bioc...

Full description

Saved in:
Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2015-01, Vol.2015, p.783761-9
Main Authors: Baralic, Ivana, Andjelkovic, Marija, Djordjevic, Brizita, Dikic, Nenad, Radivojevic, Nenad, Suzin-Zivkovic, Violeta, Radojevic-Skodric, Sanja, Pejic, Snezana
Format: Article
Language:English
Subjects:
Adenosine
Analysis
Antioxidants
Body composition
Body mass index
Chemical properties
Exercise
Free radicals
Immune system
Immunoglobulin A
Inflammation
Medicine
Nutrition research
Oxidative stress
Physical fitness
Soccer
Soccer players
Sports medicine
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The physiologic stress induced by physical activity is reflected in immune system perturbations, oxidative stress, muscle injury, and inflammation. We investigated the effect of astaxanthin (Asx) supplementation on salivary IgA (sIgA) and oxidative stress status in plasma, along with changes in biochemical parameters and total/differential white cell counts. Forty trained male soccer players were randomly assigned to Asx and placebo groups. Asx group was supplemented with 4 mg of Asx. Saliva and blood samples were collected at the baseline and after 90 days of supplementation in preexercise conditions. We observed a rise of sIgA levels at rest after 90 days of Asx supplementation, which was accompanied with a decrease in prooxidant-antioxidant balance. The plasma muscle enzymes levels were reduced significantly by Asx supplementation and by regular training. The increase in neutrophil count and hs-CRP level was found only in placebo group, indicating a significant blunting of the systemic inflammatory response in the subjects taking Asx. This study indicates that Asx supplementation improves sIgA response and attenuates muscle damage, thus preventing inflammation induced by rigorous physical training. Our findings also point that Asx could show significant physiologic modulation in individuals with mucosal immunity impairment or under conditions of increased oxidative stress and inflammation.
ISSN:1741-427X
1741-4288
DOI:10.1155/2015/783761