Vitamin D receptor gene polymorphisms and musculoskeletal injuries in professional football players

The aim of the present study was to investigate the association between vitamin D receptor (VDR) gene polymorphisms and musculoskeletal injury (MI) in elite football players. In total, 54 male professional football players were recruited from an official Italian professional championship team betwee...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2015-05, Vol.9 (5), p.1974-1978
Main Authors: MASSIDDA, MYOSOTIS, CORRIAS, LAURA, BACHIS, VALERIA, CUGIA, PAOLO, PIRAS, FRANCESCO, SCORCU, MARCO, CALÒ, CARLA M
Format: Article
Language:English
Subjects:
ApaI
Athletic recruitment
BsmI
Cell receptors
Data collection
elite athletes
FokI
Football players
genes
Genetic aspects
Genetic polymorphisms
Health aspects
Injuries
Metabolism
Metabolites
Musculoskeletal system
Polymorphism
Professional football
Properties
sport
Sports injuries
Standard deviation
Studies
Vitamin D
Vitamin deficiency
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Summary:The aim of the present study was to investigate the association between vitamin D receptor (VDR) gene polymorphisms and musculoskeletal injury (MI) in elite football players. In total, 54 male professional football players were recruited from an official Italian professional championship team between 2009 and 2013. The cohort was genotyped for the ApaI, BsmI and FokI polymorphisms and MI data were collected over four football seasons. No significant differences were identified among the genotypes in the incidence rates or severity of MI (P=0.254). In addition, no significant associations were observed between VDR polymorphisms and MI phenotypes (P=0.460). However, the results of the casewise multiple regression analysis indicated that the ApaI genotypes accounted for 18% of injury severity (P=0.002). Therefore, while the BsmI and FokI polymorphisms did not appear to be associated with the severity or incidence of MI, the ApaI genotypes may have influenced the severity of muscle injury in top-level football players.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2015.2364