Increased incidence and disparity of diagnosis of retinoblastoma patients in Guatemala

Highlights • Guatemala has a higher incidence of retinoblastoma than the United States or Europe. • There is a striking disparity in late diagnosis and mortality between indigenous and admixed children. • Elevated familial retinoblastoma is not the explanation for the increased incidence. • Point mu...

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Bibliographic Details
Published in:Cancer letters 2014-08, Vol.351 (1), p.59-63
Main Authors: Dean, Michael, Bendfeldt, Giovana, Lou, Hong, Giron, Veronica, Garrido, Claudia, Valverde, Patricia, Barnoya, Margarita, Castellanos, Mauricio, Jiménez-Morales, Silvia, Luna-Fineman, Sandra
Format: Article
Language:English
Subjects:
Age
Child, Preschool
Deoxyribonucleic acid
DNA
DNA Methylation
DNA Mutational Analysis
Ethnicity
Families & family life
Family medical history
Female
Genetic counseling
Genetic testing
Germ-Line Mutation
Guatemala
Guatemala - epidemiology
Health disparity
Health risk assessment
Healthcare Disparities
Hematology, Oncology and Palliative Medicine
Humans
Incidence
INDEL Mutation
Indians, Central American - genetics
Male
Methylation
Mortality
Mutation
Mutations
Patients
Pediatrics
Point Mutation
Promoter Regions, Genetic
Proportional Hazards Models
RB1 gene
Retinal Neoplasms - diagnosis
Retinal Neoplasms - genetics
Retinal Neoplasms - mortality
Retinoblastoma - diagnosis
Retinoblastoma - genetics
Retinoblastoma - mortality
Retinoblastoma Protein - genetics
Survival analysis
Tumors
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Description
Summary:Highlights • Guatemala has a higher incidence of retinoblastoma than the United States or Europe. • There is a striking disparity in late diagnosis and mortality between indigenous and admixed children. • Elevated familial retinoblastoma is not the explanation for the increased incidence. • Point mutations (44%) and methylation (13%) explain a modest proportion of the retinoblastoma cases. • A viral infection, nutrition or lifestyle factor could be important in the etiology of retinoblastoma in Guatemala.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.04.023