Metabolomic Identification of a Novel Pathway of Blood Pressure Regulation Involving Hexadecanedioate

High blood pressure is a major contributor to the global burden of disease and discovering novel causal pathways of blood pressure regulation has been challenging. We tested blood pressure associations with 280 fasting blood metabolites in 3980 TwinsUK females. Survival analysis for all-cause mortal...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-08, Vol.66 (2), p.422-429
Main Authors: Menni, Cristina, Graham, Delyth, Kastenmüller, Gabi, Alharbi, Nora H.J, Alsanosi, Safaa Md, McBride, Martin, Mangino, Massimo, Titcombe, Philip, Shin, So-Youn, Psatha, Maria, Geisendorfer, Thomas, Huber, Anja, Peters, Annette, Wang-Sattler, Rui, Xu, Tao, Brosnan, Mary Julia, Trimmer, Jeff, Reichel, Christian, Mohney, Robert P, Soranzo, Nicole, Edwards, Mark H, Cooper, Cyrus, Church, Alistair C, Suhre, Karsten, Gieger, Christian, Dominiczak, Anna F, Spector, Tim D, Padmanabhan, Sandosh, Valdes, Ana M
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Blood Pressure - drug effects
Blood Pressure - physiology
Carbachol - pharmacology
Cross-Sectional Studies
England
Female
Germany
Humans
Male
Metabolomics
Middle Aged
Models, Animal
Norepinephrine - pharmacology
Original
Palmitic Acids - metabolism
Rats, Inbred SHR
Rats, Inbred WKY
Signal Transduction - drug effects
Signal Transduction - physiology
Sodium Chloride - pharmacology
United Kingdom
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Summary:High blood pressure is a major contributor to the global burden of disease and discovering novel causal pathways of blood pressure regulation has been challenging. We tested blood pressure associations with 280 fasting blood metabolites in 3980 TwinsUK females. Survival analysis for all-cause mortality was performed on significant independent metabolites (P
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.115.05544