Tulane Virus as a Potential Surrogate To Mimic Norovirus Behavior in Oysters

Oyster contamination by noroviruses is an important health and economic problem. The present study aimed to compare the behaviors of Norwalk virus (the prototype genogroup I norovirus) and two culturable viruses: Tulane virus and mengovirus. After bioaccumulation, tissue distributions were quite sim...

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Bibliographic Details
Published in:Applied and Environmental Microbiology 2015-08, Vol.81 (15), p.5249-5256
Main Authors: Drouaz, Najoua, Schaeffer, Julien, Farkas, Tibor, Le Pendu, Jacques, Le Guyader, Françoise S
Format: Article
Language:English
Subjects:
Animal Structures - virology
Animals
Bioaccumulation
Caliciviridae - physiology
Cancer
Cell culture
Comparative studies
Environmental Microbiology
Host-Pathogen Interactions
Life Sciences
Mengovirus
Models, Theoretical
Norovirus
Norwalk virus
Ostreidae - virology
Oysters
Tissues
Virology
Viruses
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Summary:Oyster contamination by noroviruses is an important health and economic problem. The present study aimed to compare the behaviors of Norwalk virus (the prototype genogroup I norovirus) and two culturable viruses: Tulane virus and mengovirus. After bioaccumulation, tissue distributions were quite similar for Norwalk virus and Tulane virus, with the majority of viral particles detected in digestive tissues, while mengovirus was detected in large amounts in the gills and mantle as well as in digestive tissues. The levels of persistence of all three viruses over 8 days were comparable, but clear differences were observed over longer periods, with Norwalk and Tulane viruses displaying rather similar half-lives, unlike mengovirus, which was cleared more rapidly. These results indicate that Tulane virus may be a good surrogate for studying norovirus behavior in oysters, and they confirm the prolonged persistence of Norwalk virus in oyster tissues.
ISSN:0099-2240
1098-5336
1098-6596
DOI:10.1128/AEM.01067-15