Natriuretic peptide metabolism, clearance and degradation

Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guany...

Full description

Saved in:
Bibliographic Details
Published in:The FEBS journal 2011-06, Vol.278 (11), p.1808-1817
Main Author: Potter, Lincoln R
Format: Article
Language:English
Subjects:
ANF
Animals
atrial natriuretic peptide
atrial natriuretic peptide (ANP)
B‐type natriuretic peptide (BNP)
cardiovascular disease
cGMP
cyclic GMP
endochondrial ossification
Humans
Hydrolysis
Metabolism
Molecular biology
Natriuretic Peptides - metabolism
neprilysin
Peptides
proteolysis
receptor internalization
receptors
Signal transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C.
ISSN:1742-464X
1742-4658
DOI:10.1111/j.1742-4658.2011.08082.x