Natriuretic peptide metabolism, clearance and degradation

Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guany...

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Published in:The FEBS journal 2011-06, Vol.278 (11), p.1808-1817
Main Author: Potter, Lincoln R
Format: Article
Language:English
Subjects:
ANF
Animals
atrial natriuretic peptide
atrial natriuretic peptide (ANP)
B‐type natriuretic peptide (BNP)
cardiovascular disease
cGMP
cyclic GMP
endochondrial ossification
Humans
Hydrolysis
Metabolism
Molecular biology
Natriuretic Peptides - metabolism
neprilysin
Peptides
proteolysis
receptor internalization
receptors
Signal transduction
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container_issue 11
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container_title The FEBS journal
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description Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically distinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors, and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin, insulin-degrading enzyme, and natriuretic peptide receptor-C.
doi_str_mv 10.1111/j.1742-4658.2011.08082.x
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identifier ISSN: 1742-464X
ispartof The FEBS journal, 2011-06, Vol.278 (11), p.1808-1817
issn 1742-464X
1742-4658
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4495883
source Full-Text Journals in Chemistry (Open access); Wiley-Blackwell Read & Publish Collection
subjects ANF
Animals
atrial natriuretic peptide
atrial natriuretic peptide (ANP)
B‐type natriuretic peptide (BNP)
cardiovascular disease
cGMP
cyclic GMP
endochondrial ossification
Humans
Hydrolysis
Metabolism
Molecular biology
Natriuretic Peptides - metabolism
neprilysin
Peptides
proteolysis
receptor internalization
receptors
Signal transduction
title Natriuretic peptide metabolism, clearance and degradation
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