An overview of the metabolic functions of osteocalcin

A recent unexpected development of bone biology is that bone is an endocrine organ contributing to the regulation of a number of physiological processes. One of the functions regulated by bone through osteocalcin, an osteoblast specific hormone, is glucose homeostasis. In this overview, we explain t...

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Bibliographic Details
Published in:Reviews in endocrine & metabolic disorders 2015-06, Vol.16 (2), p.93-98
Main Authors: Wei, Jianwen, Karsenty, Gerard
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - metabolism
Diabetes
Endocrinology
Energy Metabolism - physiology
Humans
Insulin - metabolism
Insulin Secretion
Internal Medicine
Medicine
Medicine & Public Health
Osteoblasts - metabolism
Osteoblasts - physiology
Osteocalcin - metabolism
Osteocalcin - physiology
Protein Processing, Post-Translational
Receptors, G-Protein-Coupled - metabolism
Receptors, G-Protein-Coupled - physiology
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Summary:A recent unexpected development of bone biology is that bone is an endocrine organ contributing to the regulation of a number of physiological processes. One of the functions regulated by bone through osteocalcin, an osteoblast specific hormone, is glucose homeostasis. In this overview, we explain the rationale why we hypothesized that there should be a coordinated endocrine regulation between bone mass and energy metabolism. We then review the experiments that identified the endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. We also demonstrate the importance of this regulation to understand whole-body glucose homeostasis in the physiological state and in pathological conditions. Lastly we discuss the epidemiological and genetic evidence demonstrating that this function of osteocalcin is conserved in humans.
ISSN:1389-9155
1573-2606
DOI:10.1007/s11154-014-9307-7