Loading…
Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders
Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated i...
Saved in:
| Published in: | Epigenomics 2015-06, Vol.7 (3), p.503-519 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c578t-adf1cd58296a86046dd20b5bb987b557d0105218f7d3f35a2503e6ac5703853f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c578t-adf1cd58296a86046dd20b5bb987b557d0105218f7d3f35a2503e6ac5703853f3 |
| container_end_page | 519 |
| container_issue | 3 |
| container_start_page | 503 |
| container_title | Epigenomics |
| container_volume | 7 |
| creator | Vallianatos, Christina N Iwase, Shigeki |
| description | Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia. Here, we aim to summarize the molecular function of H3K4me-regulating enzymes in brain development and function. We describe four H3K4me methyltransferases (
), four demethylases (
), and two reader proteins (
) mutated in neurodevelopmental disorders. Understanding the role of these chromatin regulators in the development and maintenance of neural connections will advance therapeutic opportunities for prevention and treatment of these lifelong neurodevelopmental disorders. |
| doi_str_mv | 10.2217/epi.15.1 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4501478</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A418085419</galeid><sourcerecordid>A418085419</sourcerecordid><originalsourceid>FETCH-LOGICAL-c578t-adf1cd58296a86046dd20b5bb987b557d0105218f7d3f35a2503e6ac5703853f3</originalsourceid><addsrcrecordid>eNptkV1rFDEUhgdRbKkFf4EMeOPNrkkmX3MjlKqtWOiNgnchk5x0U2aSMckU9t-bZberVZOLfD3nzXvOaZrXGK0JweI9zH6N2Ro_a06xYGiFe_Lj-XGP8UlznvM9qqMjsuf4ZXNCOBKCdvS0uf3oc1rmArb1oSRvtNm20bUbn0sM0F53X2k7QdlsR118DJVqAywpWniAMc4ThKLH1vock4WUXzUvnB4znB_Ws-b750_fLq9XN7dXXy4vblaGCVlW2jpsLJOk51pyRLm1BA1sGHopBsaERRgxgqUTtnMd04ShDriuwaiTrF6dNR_2uvMyTGBNtZH0qObkJ522Kmqvnr4Ev1F38UFRhjAVsgq8Owik-HOBXNTks4Fx1AHikhXmu1r1lPCKvv0LvY9LCjU9RUhf1Xi1-pu60yMoH1ys_5qdqLqgWCLJKO4rtf4PVaeFyZtacefr_ZOAg0-TYs4J3DFHjNSu_6r2X2Gmdg7e_FmTI_jY7QrQPeCWsiTIxkMwoPanGuGND_Cv7i_qALxd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2291476521</pqid></control><display><type>article</type><title>Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders</title><source>Open Access: PubMed Central</source><creator>Vallianatos, Christina N ; Iwase, Shigeki</creator><creatorcontrib>Vallianatos, Christina N ; Iwase, Shigeki</creatorcontrib><description>Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia. Here, we aim to summarize the molecular function of H3K4me-regulating enzymes in brain development and function. We describe four H3K4me methyltransferases (
), four demethylases (
), and two reader proteins (
) mutated in neurodevelopmental disorders. Understanding the role of these chromatin regulators in the development and maintenance of neural connections will advance therapeutic opportunities for prevention and treatment of these lifelong neurodevelopmental disorders.</description><identifier>ISSN: 1750-1911</identifier><identifier>EISSN: 1750-192X</identifier><identifier>DOI: 10.2217/epi.15.1</identifier><identifier>PMID: 26077434</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Analysis ; Autism ; autism spectrum disorders ; brain development ; Care and treatment ; Child Development Disorders, Pervasive - genetics ; Chromatin ; Developmental Disabilities - genetics ; Diagnosis ; Disorders ; DNA methylation ; Enhancers ; Enzymes ; Epigenetics ; Gene expression ; gene regulation ; Genomes ; H3K4 methylation ; Health aspects ; Histone Demethylases - genetics ; Histone H3 ; histone methylation ; Histone-Lysine N-Methyltransferase - genetics ; Histones ; Histones - metabolism ; Humans ; Intellectual disabilities ; intellectual disability ; Intellectual Disability - genetics ; Leukemia ; Lysine ; Mental disorders ; Methylation ; Mutation ; Nervous system ; Nervous system diseases ; Neurodevelopmental disorders ; Next-generation sequencing ; Proteins ; Regulators ; RNA polymerase ; Schizophrenia ; Schizophrenia - genetics ; Sequences ; Stem cells ; Transcription (Genetics) ; Writers</subject><ispartof>Epigenomics, 2015-06, Vol.7 (3), p.503-519</ispartof><rights>Future Medicine Ltd</rights><rights>COPYRIGHT 2015 Future Medicine Ltd.</rights><rights>Copyright Future Medicine Ltd Jun 2015</rights><rights>2015 Future Medicine Ltd 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-adf1cd58296a86046dd20b5bb987b557d0105218f7d3f35a2503e6ac5703853f3</citedby><cites>FETCH-LOGICAL-c578t-adf1cd58296a86046dd20b5bb987b557d0105218f7d3f35a2503e6ac5703853f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501478/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501478/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26077434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vallianatos, Christina N</creatorcontrib><creatorcontrib>Iwase, Shigeki</creatorcontrib><title>Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders</title><title>Epigenomics</title><addtitle>Epigenomics</addtitle><description>Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia. Here, we aim to summarize the molecular function of H3K4me-regulating enzymes in brain development and function. We describe four H3K4me methyltransferases (
), four demethylases (
), and two reader proteins (
) mutated in neurodevelopmental disorders. Understanding the role of these chromatin regulators in the development and maintenance of neural connections will advance therapeutic opportunities for prevention and treatment of these lifelong neurodevelopmental disorders.</description><subject>Analysis</subject><subject>Autism</subject><subject>autism spectrum disorders</subject><subject>brain development</subject><subject>Care and treatment</subject><subject>Child Development Disorders, Pervasive - genetics</subject><subject>Chromatin</subject><subject>Developmental Disabilities - genetics</subject><subject>Diagnosis</subject><subject>Disorders</subject><subject>DNA methylation</subject><subject>Enhancers</subject><subject>Enzymes</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>gene regulation</subject><subject>Genomes</subject><subject>H3K4 methylation</subject><subject>Health aspects</subject><subject>Histone Demethylases - genetics</subject><subject>Histone H3</subject><subject>histone methylation</subject><subject>Histone-Lysine N-Methyltransferase - genetics</subject><subject>Histones</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Intellectual disabilities</subject><subject>intellectual disability</subject><subject>Intellectual Disability - genetics</subject><subject>Leukemia</subject><subject>Lysine</subject><subject>Mental disorders</subject><subject>Methylation</subject><subject>Mutation</subject><subject>Nervous system</subject><subject>Nervous system diseases</subject><subject>Neurodevelopmental disorders</subject><subject>Next-generation sequencing</subject><subject>Proteins</subject><subject>Regulators</subject><subject>RNA polymerase</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Sequences</subject><subject>Stem cells</subject><subject>Transcription (Genetics)</subject><subject>Writers</subject><issn>1750-1911</issn><issn>1750-192X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptkV1rFDEUhgdRbKkFf4EMeOPNrkkmX3MjlKqtWOiNgnchk5x0U2aSMckU9t-bZberVZOLfD3nzXvOaZrXGK0JweI9zH6N2Ro_a06xYGiFe_Lj-XGP8UlznvM9qqMjsuf4ZXNCOBKCdvS0uf3oc1rmArb1oSRvtNm20bUbn0sM0F53X2k7QdlsR118DJVqAywpWniAMc4ThKLH1vock4WUXzUvnB4znB_Ws-b750_fLq9XN7dXXy4vblaGCVlW2jpsLJOk51pyRLm1BA1sGHopBsaERRgxgqUTtnMd04ShDriuwaiTrF6dNR_2uvMyTGBNtZH0qObkJ522Kmqvnr4Ev1F38UFRhjAVsgq8Owik-HOBXNTks4Fx1AHikhXmu1r1lPCKvv0LvY9LCjU9RUhf1Xi1-pu60yMoH1ys_5qdqLqgWCLJKO4rtf4PVaeFyZtacefr_ZOAg0-TYs4J3DFHjNSu_6r2X2Gmdg7e_FmTI_jY7QrQPeCWsiTIxkMwoPanGuGND_Cv7i_qALxd</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Vallianatos, Christina N</creator><creator>Iwase, Shigeki</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders</title><author>Vallianatos, Christina N ; Iwase, Shigeki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-adf1cd58296a86046dd20b5bb987b557d0105218f7d3f35a2503e6ac5703853f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analysis</topic><topic>Autism</topic><topic>autism spectrum disorders</topic><topic>brain development</topic><topic>Care and treatment</topic><topic>Child Development Disorders, Pervasive - genetics</topic><topic>Chromatin</topic><topic>Developmental Disabilities - genetics</topic><topic>Diagnosis</topic><topic>Disorders</topic><topic>DNA methylation</topic><topic>Enhancers</topic><topic>Enzymes</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>gene regulation</topic><topic>Genomes</topic><topic>H3K4 methylation</topic><topic>Health aspects</topic><topic>Histone Demethylases - genetics</topic><topic>Histone H3</topic><topic>histone methylation</topic><topic>Histone-Lysine N-Methyltransferase - genetics</topic><topic>Histones</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Intellectual disabilities</topic><topic>intellectual disability</topic><topic>Intellectual Disability - genetics</topic><topic>Leukemia</topic><topic>Lysine</topic><topic>Mental disorders</topic><topic>Methylation</topic><topic>Mutation</topic><topic>Nervous system</topic><topic>Nervous system diseases</topic><topic>Neurodevelopmental disorders</topic><topic>Next-generation sequencing</topic><topic>Proteins</topic><topic>Regulators</topic><topic>RNA polymerase</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Sequences</topic><topic>Stem cells</topic><topic>Transcription (Genetics)</topic><topic>Writers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vallianatos, Christina N</creatorcontrib><creatorcontrib>Iwase, Shigeki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epigenomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vallianatos, Christina N</au><au>Iwase, Shigeki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders</atitle><jtitle>Epigenomics</jtitle><addtitle>Epigenomics</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>7</volume><issue>3</issue><spage>503</spage><epage>519</epage><pages>503-519</pages><issn>1750-1911</issn><eissn>1750-192X</eissn><abstract>Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellectual disabilities, autism spectrum disorders, and schizophrenia. Here, we aim to summarize the molecular function of H3K4me-regulating enzymes in brain development and function. We describe four H3K4me methyltransferases (
), four demethylases (
), and two reader proteins (
) mutated in neurodevelopmental disorders. Understanding the role of these chromatin regulators in the development and maintenance of neural connections will advance therapeutic opportunities for prevention and treatment of these lifelong neurodevelopmental disorders.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>26077434</pmid><doi>10.2217/epi.15.1</doi><tpages>17</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1750-1911 |
| ispartof | Epigenomics, 2015-06, Vol.7 (3), p.503-519 |
| issn | 1750-1911 1750-192X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4501478 |
| source | Open Access: PubMed Central |
| subjects | Analysis Autism autism spectrum disorders brain development Care and treatment Child Development Disorders, Pervasive - genetics Chromatin Developmental Disabilities - genetics Diagnosis Disorders DNA methylation Enhancers Enzymes Epigenetics Gene expression gene regulation Genomes H3K4 methylation Health aspects Histone Demethylases - genetics Histone H3 histone methylation Histone-Lysine N-Methyltransferase - genetics Histones Histones - metabolism Humans Intellectual disabilities intellectual disability Intellectual Disability - genetics Leukemia Lysine Mental disorders Methylation Mutation Nervous system Nervous system diseases Neurodevelopmental disorders Next-generation sequencing Proteins Regulators RNA polymerase Schizophrenia Schizophrenia - genetics Sequences Stem cells Transcription (Genetics) Writers |
| title | Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T09%3A48%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Disrupted%20intricacy%20of%20histone%20H3K4%20methylation%20in%20neurodevelopmental%20disorders&rft.jtitle=Epigenomics&rft.au=Vallianatos,%20Christina%20N&rft.date=2015-06-01&rft.volume=7&rft.issue=3&rft.spage=503&rft.epage=519&rft.pages=503-519&rft.issn=1750-1911&rft.eissn=1750-192X&rft_id=info:doi/10.2217/epi.15.1&rft_dat=%3Cgale_pubme%3EA418085419%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c578t-adf1cd58296a86046dd20b5bb987b557d0105218f7d3f35a2503e6ac5703853f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2291476521&rft_id=info:pmid/26077434&rft_galeid=A418085419&rfr_iscdi=true |