Ki-67 as a prognostic marker in early-stage non-small cell lung cancer in Asian patients: a meta-analysis of published studies involving 32 studies

• Published in: BMC cancer 2015-07, Vol.15 (1), p.520-520, Article 520
• Main Authors: Wen, Song, Zhou, Wei, Li, Chun-Ming, Hu, Juan, Hu, Xiao-Ming, Chen, Ping, Shao, Guo-Liang, Guo, Wu-Hua
• Format: Article
• Language: English
• Subjects: Analysis; Asian Continental Ancestry Group; Biomarkers, Tumor; Cancer; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Clinical medicine; Diagnosis; Female; Gender; Gene Expression; Humans; Ki-67 Antigen - genetics; Ki-67 Antigen - metabolism; Lung cancer; Lung cancer, Non-small cell; Lung cancer, Small cell; Lung Neoplasms - metabolism; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Medical prognosis; Meta-analysis; Neoplasm Staging; Oncology, Experimental; Pathology; Prognosis; Proportional Hazards Models; Publication Bias
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-015-1524-2

Despite the large number of published papers analyzing the prognostic role of Ki-67 in NSCLC, it is still not considered an established factor for routine use in clinical practice. The present meta-analysis summarizes and analyses the associations between Ki-67 expression and clinical outcome in NSCLC patients. PubMed, Cochrane, and Embase databases were searched systematically using identical search strategies. The impacts of Ki-67 expression on survival in patients with NSCLC and NSCLC subtypes were evaluated. Furthermore, the association between Ki-67 expression and the clinicopathological features of NSCLC were evaluated. In total, 32 studies from 30 articles met the inclusion criteria, involving 5600 patients. Meta-analysis results suggested that high Ki-67 expression was negatively associated with overall survival (OS; HR = 1.59, 95 % CI 1.35-1.88, P