Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

• Published in: Journal of translational medicine 2015-07, Vol.13 (1), p.230-230, Article 230
• Main Authors: Massanella, Marta, Gómez-Mora, Elisabet, Carrillo, Jorge, Curriu, Marta, Ouchi, Dan, Puig, Jordi, Negredo, Eugènia, Cabrera, Cecilia, Clotet, Bonaventura, Blanco, Julià
• Format: Article
• Language: English
• Subjects: Adult; Analysis; Antiretroviral Therapy, Highly Active; Biochemistry; Care and treatment; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - pathology; CD57 Antigens - metabolism; CD8-Positive T-Lymphocytes - immunology; Cell Compartmentation; Cell Death; Cell differentiation; Cell Differentiation - immunology; Drug therapy; Female; Health aspects; Highly active antiretroviral therapy; HIV (Viruses); HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - pathology; HIV patients; Humans; Immunologic Memory; Male; Memory (Computers); Middle Aged; T cells; T-Lymphocyte Subsets - immunology
• ISSN: 1479-5876; 1479-5876
• DOI: 10.1186/s12967-015-0601-2

High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. However, the relationship between cell death and T-cell differentiation is still unclear. We have analyzed cell death, immunosenescence and differentiation parameters in HAART-treated subjects (VL