Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery

High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. However, the relationship between cell death and T-cell differentiation is still unclear. We ha...

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Published in:Journal of translational medicine 2015-07, Vol.13 (1), p.230-230, Article 230
Main Authors: Massanella, Marta, Gómez-Mora, Elisabet, Carrillo, Jorge, Curriu, Marta, Ouchi, Dan, Puig, Jordi, Negredo, Eugènia, Cabrera, Cecilia, Clotet, Bonaventura, Blanco, Julià
Format: Article
Language:English
Subjects:
Adult
Analysis
Antiretroviral Therapy, Highly Active
Biochemistry
Care and treatment
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - pathology
CD57 Antigens - metabolism
CD8-Positive T-Lymphocytes - immunology
Cell Compartmentation
Cell Death
Cell differentiation
Cell Differentiation - immunology
Drug therapy
Female
Health aspects
Highly active antiretroviral therapy
HIV (Viruses)
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - pathology
HIV patients
Humans
Immunologic Memory
Male
Memory (Computers)
Middle Aged
T cells
T-Lymphocyte Subsets - immunology
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creator Massanella, Marta
Gómez-Mora, Elisabet
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Ouchi, Dan
Puig, Jordi
Negredo, Eugènia
Cabrera, Cecilia
Clotet, Bonaventura
Blanco, Julià
description High levels of ex vivo CD4 T-cell death and the accumulation of highly differentiated and/or immunosenescent T cells have been associated with poor CD4 T-cell recovery in treated HIV-infected individuals. However, the relationship between cell death and T-cell differentiation is still unclear. We have analyzed cell death, immunosenescence and differentiation parameters in HAART-treated subjects (VL
doi_str_mv 10.1186/s12967-015-0601-2
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subjects Adult
Analysis
Antiretroviral Therapy, Highly Active
Biochemistry
Care and treatment
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - pathology
CD57 Antigens - metabolism
CD8-Positive T-Lymphocytes - immunology
Cell Compartmentation
Cell Death
Cell differentiation
Cell Differentiation - immunology
Drug therapy
Female
Health aspects
Highly active antiretroviral therapy
HIV (Viruses)
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - pathology
HIV patients
Humans
Immunologic Memory
Male
Memory (Computers)
Middle Aged
T cells
T-Lymphocyte Subsets - immunology
title Increased ex vivo cell death of central memory CD4 T cells in treated HIV infected individuals with unsatisfactory immune recovery
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