Drugging the unfolded protein response in acute leukemias

The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical network in selection, adaptation, and survival of cancer cells. While previous reviews focus...

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Bibliographic Details
Published in:Journal of hematology and oncology 2015-07, Vol.8 (1), p.87-87, Article 87
Main Authors: Kharabi Masouleh, Behzad, Chevet, Eric, Panse, Jens, Jost, Edgar, O'Dwyer, Michael, Bruemmendorf, Tim H, Samali, Afshin
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Cancer
Cell Survival
Funding
Health aspects
Hematology
Homeostasis
Humans
Kinases
Leukemia
Leukemia - genetics
Life Sciences
Mutation
Oncology
Protein folding
Review
Signal Transduction
Stem cells
Studies
Transcription factors
Unfolded Protein Response - genetics
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Summary:The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical network in selection, adaptation, and survival of cancer cells. While previous reviews focused mainly on solid cancer cells, in this review, we summarize the recent findings focusing on acute leukemias. We take into account the impact of the underlying genetic alterations of acute leukemia cells, the leukemia stem cell pool, and provide an outline on the current genetic, clinical, and therapeutic findings. Furthermore, we shed light on the important oncogene-specific regulation of individual UPR signaling branches and the therapeutic relevance of this information to answer the question if the UPR could be an attractive novel target in acute leukemias.
ISSN:1756-8722
1756-8722
DOI:10.1186/s13045-015-0184-7