Pediatric reference ranges for acute kidney injury biomarkers

Background Novel urinary biomarkers are useful for the prediction of acute kidney injury (AKI). Most promising are the urine markers NGAL, IL-18, KIM-1, and LFABP. Each of these has shown considerable promise diagnosing AKI earlier than serum creatinine (Scr) using disease controls. We set out to de...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2015-04, Vol.30 (4), p.677-685
Main Authors: Bennett, Michael R., Nehus, Edward, Haffner, Christopher, Ma, Qing, Devarajan, Prasad
Format: Article
Language:English
Subjects:
Acute Kidney Injury - diagnosis
Acute Kidney Injury - urine
Acute renal failure
Acute-Phase Proteins - urine
Adolescent
Age
Biological markers
Biomarkers
Biomarkers - urine
Child
Child, Preschool
Clinical trials
Creatinine
Cytokines
Diagnosis
Fatty Acid-Binding Proteins - urine
Fatty acids
Gender differences
Genetic aspects
Hepatitis A Virus Cellular Receptor 1
Humans
Interleukin-18 - urine
Kidney diseases
Lipocalin-2
Lipocalins - urine
Medicine
Medicine & Public Health
Membrane Glycoproteins - urine
Nephrology
Original Article
Pediatrics
Physiological aspects
Prognosis
Proto-Oncogene Proteins - urine
Receptors, Virus
Reference Values
Urine
Urology
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Summary:Background Novel urinary biomarkers are useful for the prediction of acute kidney injury (AKI). Most promising are the urine markers NGAL, IL-18, KIM-1, and LFABP. Each of these has shown considerable promise diagnosing AKI earlier than serum creatinine (Scr) using disease controls. We set out to determine reference levels of these markers in a healthy pediatric population. Methods Urine was collected from 368 healthy children and assayed for NGAL, IL-18, KIM-1, and LFABP using commercially available kits or assay materials. Analysis of biomarkers by linear regression and according to age groups (3–
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-014-2989-y